Effect of implant loading protocols and associated factors on the success rate of implant therapy: A retrospective clinical study.

Statement Of Problem: Although immediate implant loading has shown promising clinical results and high survival rates, an increased risk of implant failure and complications has been reported. Achieving consistently predictable outcomes with this approach remains a challenge, but evidence-based guidelines to assist in selecting suitable patients are lacking.

Purpose: The purpose of this retrospective clinical study was to investigate the success rate, survival rate, and complications of immediate implant loading compared with early and delayed loading.

Routine practice data of three cancer entities: Comparison among cancer registry and health insurance data.

Introduction: Claims data and cancer registry data are valuable secondary data sources for addressing health service research questions. This study provides a thorough insight into the comparability of data from health insurance companies and cancer registries in Germany regarding breast, prostate, and lung cancer patients and their treatment.

Methods: For this study claims data of the InGef database and data of the Cancer Registry of Rhineland-Palatinate were used to identify patients living in Rhineland-Palatinate with an incident breast, prostate, or lung cancer diagnosis between Jan.

Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS.

Mutations in the human Superoxide dismutase 1 (hSOD1) gene are well-established cause of the motor neuron disease ALS. Patients and transgenic (Tg) ALS model mice carrying mutant variants develop hSOD1 aggregates in the CNS. We have identified two hSOD1 aggregate strains, which both transmit spreading template-directed aggregation and premature fatal paralysis when inoculated into adult transgenic mice.

Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry.

In solution, the charge of a protein is intricately linked to its stability, but electrospray ionization distorts this connection, potentially limiting the ability of native mass spectrometry to inform about protein structure and dynamics. How the behavior of intact proteins in the gas phase depends on the presence and distribution of ionizable surface residues has been difficult to answer because multiple chargeable sites are present in virtually all proteins. Turning to protein engineering, we show that ionizable side chains are completely dispensable for charging under native conditions, but if present, they are preferential protonation sites.

Effect of crown height on the screw joint stability of zirconia screw-retained crowns.

Statement Of Problem: Medium- to long-term data for the performance of zirconia crowns with titanium (Ti) bases are sparse, particularly when the crown height space and occlusal loads are high.

Purpose: The purpose of this in vitro study was to assess the effect of the height of zirconia screw-retained implant crowns with a Ti base on the screw joint stability after cyclic loading. A secondary aim was to investigate the survival of zirconia crowns of different heights after cyclic loading.

Effect of Crown Height on the Screw Stability of Titanium Screw-Retained Crowns.

Purpose: The aim of this in vitro study was to evaluate the effect of crown height on the screw stability of screw-retained titanium implant crowns subjected to cyclic loading conditions.

Materials And Methods: Twenty-one implants with internal hex connections were placed in epoxy resin holders. Mandibular first molar screw-retained titanium implant crowns with UCLA type, crown-abutment connections were CAD/CAM fabricated.

Publisher Correction: In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model.

Background: High night-to-night variability in obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Obstructive apneas are characterized by intermittent deoxygenation-reoxygenation and intrathoracic pressure swings during ineffective inspiration against occluded upper airways.

Objective: We elucidated the effect of repeated exposure to transient OSA conditions simulated by intermittent negative upper airway pressure (INAP) on the development of an AF substrate.

Weighted mandibular complete denture fabricated by using selective laser melting: A clinical report.

The rehabilitation of patients with severely resorbed mandibular ridges can be a clinical challenge when rehabilitation with endosteal implants is not the elected treatment. Historically, weighted mandibular complete dentures have been used successfully to manage patients with severely resorbed ridges, and the weight of their cast metal has been calculated by using the weight of the wax and the density of the alloy. This clinical report presents the management of an 87-year-old woman with a severely resorbed mandibular ridge by using a weighted mandibular complete denture fabricated by using selective laser melting (SLM) technology in which the weight of the metal base was calculated by using the volume of the digital file used for manufacture.

Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.

In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM). CatA-mediated degradation of extracellular peptides may contribute to ECM remodeling and left ventricular (LV) dysfunction. Here, we aimed to evaluate the effects of CatA overexpression on LV remodeling.

The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway.

Post-translationally modified peptides are involved in many aspects of plant growth and development. The maturation of these peptides from their larger precursors is still poorly understood. We show here that the biogenesis of CLEL6 and CLEL9 peptides in requires a series of processing events in consecutive compartments of the secretory pathway.

Effect of coded healing abutment height and position on the trueness of digital intraoral implant scans.

Statement Of Problem: Information regarding the effect of the height and position of a coded healing abutment (CHA) on the trueness of intraoral digital scans is lacking.

Purpose: The purpose of this in vitro study was to investigate the effect of the height and position of a scannable CHA on the trueness (distance and angular deviations) of intraoral digital scans.

Material And Methods: Scannable CHAs (BellaTek Encode Impression system; Zimmer Biomet Dental) were used in 2 different height pairs (3 mm and 8 mm) on 2 implants at mandibular left second and first molar positions.

Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion.

After myocardial infarction, remote ventricular remodeling and atrial cardiomyopathy progress despite successful revascularization. In a rat model of ventricular ischemia/reperfusion, pharmacological inhibition of the protease activity of cathepsin A initiated at the time point of reperfusion prevented extracellular matrix remodeling in the atrium and the ventricle remote from the infarcted area. This scenario was associated with preservation of more viable ventricular myocardium and the prevention of an arrhythmogenic and functional substrate for atrial fibrillation.

In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants.

Braiding of Nitinol micro wires is an established technology for the manufacturing of fine-meshed neurovascular implants for tortuous vessel geometries. Electropolishing of wires before the braiding process has the potential to improve the in vitro behaviour in terms of thrombogenicity and endothelial cell proliferation. In this study, we present the first in vitro investigation of braided electropolished/blue oxide Nitinol samples in a blood flow loop, showing a significantly lower activation of the coagulation pathway (represented by the TAT III marker) and a tendency towards reduced platelet adhesion.

A comparison of implant complications and failures between the maxilla and the mandible.

Statement Of Problem: Identifying factors that affect the clinical outcomes of implant therapy is important.

Purpose: The purpose of this retrospective study was to determine whether implant location was a factor affecting the complication and failure rates of single-tooth implant-supported restorations in a predoctoral setting.

Material And Methods: The charts of 431 patients treated with a surgically placed dental implant and restored with a single crown in the predoctoral clinic were analyzed.

Physicochemical code for quinary protein interactions in .

How proteins sense and navigate the cellular interior to find their functional partners remains poorly understood. An intriguing aspect of this search is that it relies on diffusive encounters with the crowded cellular background, made up of protein surfaces that are largely nonconserved. The question is then if/how this protein search is amenable to selection and biological control.

Intestinal Barrier Function and the Gut Microbiome Are Differentially Affected in Mice Fed a Western-Style Diet or Drinking Water Supplemented with Fructose.

The consumption of a Western-style diet (WSD) and high fructose intake are risk factors for metabolic diseases. The underlying mechanisms are largely unclear. To unravel the mechanisms by which a WSD and fructose promote metabolic disease, we investigated their effects on the gut microbiome and barrier function.

Evaluation of mineral content in healthy permanent human enamel by Raman spectroscopy.

Background: An understanding of tooth enamel mineral content using a clinically viable method is essential since variations in mineralization may serve as an early precursor of a dental health issues, and may predict progression and architecture of decay in addition to assessing the success and effectiveness of the remineralization strategies.

Material And Methods: Twenty two human incisor teeth were obtained in compliance with the NIH guidelines and site specifically imaged with Raman microscope. The front portion of the teeth was divided into apical, medium and cervical regions and subsequently imaged with Raman microscope in these three locations.

Mechanical properties and DIC analyses of CAD/CAM materials.

Background: This study compared two well-known computer-aided-design/computer-aided-manufactured (CAD/CAM) blocks (Paradigm MZ100 [3M ESPE] and Vitablocs Mark II [Vita] in terms of fracture toughness (Kic), index of brittleness (BI) and stress/strain distributions.

Material And Methods: Three-point bending test was used to calculate the fracture toughness, and the relationship between the Kic and the Vickers hardness was used to calculate the index of brittleness. Additionally, digital image correlation (DIC) was used to analyze the stress/strain distribution on both materials.

Tricking a Protein To Swap Strands.

Despite continuing interest in partly unfolded proteins as precursors for aggregation and adverse gain-of-function in human disease, there is yet little known about the local transitions of native structures that possibly lead to such intermediate states. To target this problem, we present here a protein-design strategy that allows real-time detection of rupture and swapping of complete secondary-structure elements in globular proteins-molecular events that have previously been inaccessible experimental analysis. The approach is applied to the dynamic β-barrel of SOD1, associated with pathologic aggregation in the neurodegenerative disease ALS.

Microtensile bond strength between a UDMA fiber post and different resin cements: Effect of pre-surface treatment.

During a fiber post cementation, bonding failure often occurs at the junction between the fiber-post and resin-cement. Because this failure requires better characterization, we evaluated if different post surface treatment can affect the bond strength of urethane dimethacrylate (UDMA) fiber-posts with resin-cements. Three groups were created: G1: no treatment/silane; G2: ethyl alcohol (96° GL)/silane; G3: 24% HO/silane and further divided into four subgroups: I-Unicem/3MESPE; II-BisCem/Bisco; III-Panavia SA/Kuraray and IV-DuoLink/Bisco.

Are different generations of CAD/CAM milling machines capable to produce restorations with similar quality?

Background: Different CAD/CAM machines' generation may impact the restoration overall quality. The present study evaluated the marginal fit of CAD/CAM restorations manufactured with different generations of CEREC milling unit systems.

Material And Methods: Sixteen typodont teeth were divided into two groups (n=8) according to the machine's generation assigned.

Comparison of Preprosthetic Implant Complications and Failures Between Obese and Nonobese Patients.

Purpose: Obesity as a systemic risk factor associated with implant failure or other complications has not been studied. The aim of this study was to compare the frequency of implant failure and complications between obese and nonobese patients.

Materials And Methods: Charts from 220 partially edentulous patients with 321 implants were examined for demographic information, medical health history, diabetes, smoking, patient-reported height and weight, periodontal status (no, mild, moderate, or severe periodontitis), tooth number, date of the implant and prosthesis placement, and treatment notes pertinent to the complications or failure.