Publications by authors named "Lisa Kieweg"
Article Synopsis
- Human adenoviruses (HAdVs) need to decondense and activate their viral genomes for replication by manipulating host chromatin structures, particularly with the involvement of a host protein called KAP1.
- KAP1, a transcription factor that affects chromatin organization, becomes modified during HAdV infection, reducing its ability to restrict viral replication through processes like SUMO modification.
- The study highlights the interplay between adenoviral proteins and host factors like KAP1 and SPOC1, shedding light on early mechanisms that influence the effectiveness of HAdV infection.
