The phenylephrine concentration-response relationship for blood pressure after nasal delivery in children.

Background: Intranasal phenylephrine is commonly used to vasoconstrict the nasal mucosa, reducing bleeding associated with nasotracheal intubation or endoscopic sinus surgery. There are few data quantifying either absorption pharmacokinetics or phenylephrine concentration effect on blood pressure in children.

Methods: Published observations of plasma concentration and blood pressure changes after phenylephrine nasal administration (0.

Hemodynamic responses and plasma phenylephrine concentrations associated with intranasal phenylephrine in children.

Introduction: Intranasal phenylephrine, an alpha-1 adrenergic agonist, causes vasoconstriction of the nasal mucosa and is used to reduce bleeding associated with nasotracheal intubation or endoscopic sinus surgery. The purpose of this study was to describe the hemodynamic effects associated with plasma phenylephrine concentrations following topical intranasal administration of 0.25% and 0.