Publications by authors named "Lisa Hirose"
Article Synopsis
- - The study reviews the effectiveness of self-management interventions for inflammatory bowel disease (IBD) by analyzing 50 randomized controlled trials from 2000 to 2020, focusing on various outcome measures like psychological health and quality of life.
- - The results showed that about 66% of these studies reported significant improvements, particularly in symptom management; many successful interventions involved providing information and included individual participation and multidisciplinary healthcare teams.
- - The conclusion emphasizes that tailored, participatory approaches focusing on symptom management and information delivery can enhance self-management behaviors in patients with IBD.
Background/aims: Risks of long-term steroid use in patients with ulcerative colitis (UC) outweigh the benefits, thus dosing should be tapered once a response is achieved. Colonoscopy is a key technique for assessing disease severity and optimizing treatment involving steroids. This retrospective longitudinal cohort study of patients with UC explored factors associated with the duration of systemic steroid use.
View Article and Find Full Text PDFBackground: Skeletal muscle has an important role in regulating whole-body energy homeostasis, and energy production depends on the efficient function of mitochondria. We demonstrated previously that AT-rich interactive domain 5b (Arid5b) knockout (Arid5b) mice were lean and resistant to high-fat diet (HFD)-induced obesity. While a potential role of Arid5b in energy metabolism has been suggested in adipocytes and hepatocytes, the role of Arid5b in skeletal muscle metabolism has not been studied.
View Article and Find Full Text PDFBackground: For the diagnosis and treatment of adult T-cell leukemia/lymphoma (ATLL) caused by human T-lymphotropic virus type 1 (HTLV-1) are required therapeutic modalities urgently. Non-human primate models for ATLL would provide a valuable information for clinical studies. We did a pilot study to establish an ATLL non-human primate model using common marmosets (Callithrix jacchus).
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- Oncolytic virotherapies, like coxsackievirus B3 (CVB3), show promise in treating cancer by targeting tumors while avoiding normal cells; the challenge has been CVB3’s non-specific toxicity to healthy cells.* -
- Researchers improved CVB3’s safety by inserting microRNA target sequences that specifically respond to miR-34a/c, which is more prevalent in normal cells, preventing viral replication in these tissues.* -
- The resulting double-miR-34a targeting virus (53a-CVB) was found to be minimally toxic to normal cells while effectively attacking cancer cells in mice, marking a significant advancement for safer anti-cancer treatments.*
Krüppel-like factor 1 (KLF1), a transcription factor controlling definitive erythropoiesis, is involved in sequential control of terminal cell division and enucleation via fine regulation of key cell cycle regulator gene expression in erythroid lineage cells. Type IV congenital dyserythropoietic anemia (CDA) is caused by a monoallelic mutation at the second zinc finger of KLF1 (c.973G>A, p.
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- Developing effective and low-cost anticancer drugs is difficult due to the need for low toxicity and high efficacy in chemotherapy.
- The study utilizes a computational approach focusing on molecular pathways to identify existing drugs that can be repurposed for cancer treatment, analyzing gene expression data from 1,112 drugs across 66 human cell lines.
- The researchers validated their predictions through in vitro experiments, ultimately identifying multiple potential anticancer drugs and showcasing the effectiveness of their pathway-based method for drug repositioning.
The aims of this study were to examine the plasma concentrations of inflammatory mediators including cytokines induced by a single bout of eccentric exercise and again 4 weeks later by a second bout of eccentric exercise of the same muscle group. Ten untrained male subjects performed two bouts of the eccentric exercise involving the elbow flexors (6 sets of 5 repetitions) separated by four weeks. Changes in muscle soreness, swelling, and function following exercise were compared between the bouts.
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