Treatment of squamous cell carcinoma with intralesional 5-Fluorouracil.

Background: 5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen's disease, and keratoacanthoma.

Objective: We sought to determine whether intralesional 5-FU might be effective in treating a patient with SCC.

Methods: A patient with SCC at the junction of the right alar crease and right nasolabial fold was treated with eight weekly injections of 5-FU, with doses ranging from 0.