Publications by authors named "Lisa Fricke"
The prognosis for pancreatic cancer remains poor. Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model systems such as organoids have the potential to substantially increase the depth of information from biopsy material by functional and molecular characterization.
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- Researchers analyzed ischaemic stroke (IS) cases that occurred within eight days of COVID-19 onset to determine if they have a unique genetic background compared to other stroke types.
- Using a method called SUPERGNOVA, they identified specific genomic regions related to large artery atherosclerosis (LAA) and cardioembolic stroke (CES) from a cohort of 73 IS-COV patients and 701 control subjects.
- The study found four genetic loci associated with CES and significant polygenic risk scores for LAA, suggesting IS-COV patients may share genetic traits with these stroke subtypes; more research is needed to see if these traits are specific to viral infection or common in the general population.
The dysplasia grading of Barrett's esophagus (BE), based on the histomorphological assessment of formalin-fixed, paraffin-embedded (FFPE) tissue, suffers from high interobserver variability leading to an unsatisfactory prediction of cancer risk. Thus, pre-analytic preservation of biological molecules, which could improve risk prediction in BE enabling molecular and genetic analysis, is needed. We aimed to evaluate such a molecular pre-analytic fixation tool, PAXgene-fixed paraffin-embedded (PFPE) biopsies, and their suitability for histomorphological BE diagnostics in comparison to FFPE.
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- Scientists are trying to figure out if the gut microbiome (the tiny bacteria in our stomachs) affects COVID-19 or if COVID-19 affects the microbiome, but it's really complicated to study.
- In a study, they looked at samples from people with COVID-19 and noticed that bacteria in their gut and mouth changed depending on how sick they were.
- They discovered that having certain bacteria could help predict how well someone would do with COVID-19, and a stable gut microbiome might lead to a better recovery.
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant T (MAIT) cells, innate-like T cells with potent antimicrobial effector function, in patients with mild and severe COVID-19 by multicolour flow cytometry.
View Article and Find Full Text PDFObjectives: Renal denervation is an interventional approach aiming to reduce high blood pressure. Its efficacy is subject of controversial debate. We analyzed autonomic function in patients undergoing renal denervation to identify responders.
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