Publications by Lisa Endo

Publications by authors named "Lisa Endo"

HLA

July 2024

- The study investigates the link between HLA genotypes and the severity of COVID-19 in 209 Japanese patients, identifying how specific alleles correlate with severe respiratory cases over different epidemic periods (pre-Omicron and Omicron).
- Significant associations were found, particularly with alleles HLA-DQA1*01:03 and HLA-DQB1*06:01, showing higher frequencies in severe COVID-19 cases compared to non-severe cases, primarily during the pre-Omicron period.
- There was a strong correlation between the two significant alleles (r = 0.91), indicating they are often inherited together, and their presence in the severe group highlights potential genetic factors influencing COVID-19

Lisa Endo's recent research focuses on the genetic factors influencing the severity of COVID-19, specifically examining the HLA gene system.
The study highlighted a notable association between specific HLA alleles (HLA-DQA1*01:03 and DQB1*06:01) and the risk of developing severe pneumonia in patients infected with COVID-19.
Published in the journal HLA, the findings contribute to the understanding of the immune response to COVID-19, particularly within the Japanese population, and suggest potential avenues for personalized treatment approaches.