Introduction to the cognitive hospital.

The third industrial revolution has radically impacted the transformation of hospitals. Through the adoption of key digital technologies, hospitals have become more accessible, flexible, organised, responsive and able to deliver more personalised care. The digitalisation of patient health records, one of the most remarkable achievements to date in healthcare management, has enabled new opportunities, including the idea of hospitals evolving to become artificially intelligent.

Immediate and delayed effects of suppression and mindfulness as emotion regulation strategies.

Background & Objectives: Emotion regulation is an integral component of multiple physical and psychological functions, and problems with emotion regulation are thought to be involved with the development of psychological disorders. Most laboratory research on emotion regulation has been limited to investigating short-term impact during a single session.

Design & Methods: In the current study, we investigated the potential delayed consequences of the short-term use of two emotion regulation strategies: mindfulness and suppression.

Age Differences in Negative, but Not Positive, Rumination.

Objectives: The main objective of this study was to determine whether there are age differences in positive and negative repetitive thought (ie, rumination).

Method: Young adults (ages 19-39; n = 114) and older adults (ages 60-85; n = 88) completed measures of negative and positive rumination. Bayesian analyses were used to determine whether age differences were present for both negative (young > old) and positive (old > young) rumination.

Empathic Understanding: Benefits of Perspective-Taking and Facial Mimicry Instructions are Mediated by Self-Other Overlap.

The current study sought to better understand the utility of two strategies - perspective-taking and facial mimicry - proposed to increase empathic responding. Thirty-seven female participants were presented an interpersonal situation (a betrayal) that would elicit the use of empathic responding to achieve conflict resolution between friends. Each participant was given instructions to partake in either perspective-taking, facial mimicry, or to remain neutral (control condition).

Episodic future thought: contributions from working memory.

The ability to imagine hypothetical events in one's personal future is thought to involve a number of constituent cognitive processes. We investigated the extent to which individual differences in working memory capacity contribute to facets of episodic future thought. College students completed simple and complex measures of working memory and were cued to recall autobiographical memories and imagine future autobiographical events consisting of varying levels of specificity (i.

Information content moderates positivity and negativity biases in memory.

Two experiments examined the impact of encoding conditions and information content in memory for positive, neutral, and negative pictures. We examined the hypotheses that the positivity effect in memory (i.e.

The illusion of the positive: the impact of natural and induced mood on older adults' false recall.

Recent research suggests that affective and motivational processes can influence age differences in memory. In the current study, we examine the impact of both natural and induced mood state on age differences in false recall. Older and younger adults performed a version of the Deese-Roediger-McDermott (DRM; Roediger & McDermott, 1995 , Journal of Experimental Psychology: Learning, Memory, and Cognition, 21, 803) false memory paradigm in either their natural mood state or after a positive or negative mood induction.

Mood, motivation, and misinformation: aging and affective state influences on memory.

Normative age differences in memory have typically been attributed to declines in basic cognitive and cortical mechanisms. The present study examined the degree to which dominant everyday affect might also be associated with age-related memory errors using the misinformation paradigm. Younger and older adults viewed a positive and a negative event, and then were exposed to misinformation about each event.

Changes in mindfulness, well-being, and sleep quality in college students through taijiquan courses: a cohort control study.

Objectives: This study sought to determine whether participants in taijiquan classes would report increases in mindfulness greater than that of a comparison group, and whether changes in mindfulness were associated with improvements in mood, perceived stress, self-regulatory self-efficacy, and sleep quality.

Design: The study design was quasi-experimental with repeated measures.

Settings/location: The study was set in a midsized public university.

Longitudinal relationships between resources, motivation, and functioning.

Objectives: We investigated how fluctuations and linear changes in health and cognitive resources influence the motivation to engage in complex cognitive activity and the extent to which motivation mediated the relationship between changing resources and cognitively demanding activities.

Method: Longitudinal data from 332 adults aged 20-85 years were examined. Motivation was assessed using a composite of Need for Cognition and Personal Need for Structure and additional measures of health, sensory functioning, cognitive ability, and self-reported activity engagement.

Cognitive consequences of expressive regulation in older adults.

Previous research has suggested that older and young adults are equally able to regulate their outward expressions of emotion and that the regulation of emotional expression in younger adults results in decreased memory for the emotional stimulus. In the current study, we examined whether older adults show this same memory effect. Older and young adults viewed positive and negative emotional pictures under instructions to view the pictures naturally, enhance their facial expressions, or suppress their facial expressions.

Task demands moderate stereotype threat effects on memory performance.

Previous research has demonstrated that older adults' memory performance is adversely affected by the explicit activation of negative stereotypes about aging. In this study, we examined the impact of stereotype threat on recognition memory, with specific interest in (a) the generalizability of previously observed effects, (b) the subjective experience of memory, and (c) the moderating effects of task demands. Older participants subjected to threat performed worse than did those in a nonthreat condition but only when performance constraints were high (i.

Age differences in proactive interference, working memory, and abstract reasoning.

It has been hypothesized that older adults are especially susceptible to proactive interference (PI) and that this may contribute to age differences in working memory performance. In young adults, individual differences in PI affect both working memory and reasoning ability, but the relations between PI, working memory, and reasoning in older adults have not been examined. In the current study, young, old, and very old adults performed a modified operation span task that induced several cycles of PI buildup and release as well as two tests of abstract reasoning ability.

Age-related changes in neural activity during performance matched working memory manipulation.

A long-standing assumption in the cognitive aging literature is that performance on working memory (WM) tasks involving serial recall is relatively unaffected by aging, whereas tasks that require the rearrangement of items prior to recall are more age-sensitive. Previous neuroimaging studies of WM have found age-related increases in neural activity in frontoparietal brain regions during simple maintenance tasks, but few have examined whether there are age-related differences that are specific to rearranging WM items. In the current study, older and younger adults' brain activity was monitored using functional magnetic resonance imaging (fMRI) as they performed WM tasks involving either maintenance or manipulation (letter-number sequencing).

Viewing instructions impact emotional memory differently in older and young adults.

The current study examines how the instructions given during picture viewing impact age differences in incidental emotional memory. Previous research has suggested that older adults' memory may be better when they make emotional rather than perceptual evaluations of stimuli and that their memory may show a positivity bias in tasks with open-ended viewing instructions. Across two experiments, participants viewing photographs either received open-ended instructions or were asked to make emotionally focused (Experiment 1) or perceptually focused (Experiment 2) evaluations.

Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease.

Introduction: Gliadin proteins play a key role in the pathogenesis of celiac disease; however, as a screen for celiac disease, anti-gliadin antibody testing has been replaced by the more sensitive and specific serological assays for transglutaminase autoantibodies (TGAA). A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity.

Methods: Sera were collected prospectively from children with an increased risk for celiac disease as part of an ongoing study at Denver, and studied for the development of celiac autoimmunity.

Impact of celiac autoimmunity on children with type 1 diabetes.

Objective: Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear.

Study Design: We compared 71 screening-identified TG+ with 63 matched TG- children with TIDM. Growth, bone density, and diabetes control measures were obtained.

Age differences in item manipulation span: the case of letter-number sequencing.

The authors report 2 experiments in which they examined age differences in working memory tasks involving complex item manipulation (i.e., letter-number sequencing).

Saying versus touching: age differences in short-term memory are affected by the type of response.

We examined whether the type of response used to report items recalled from short-term memory affects the age difference in verbal and spatial memory spans. Younger and older adults viewed either a series of letters or a series of locations in a grid, and then they reported their memory for the items either vocally or by using a touch screen. Overall, age differences were larger for spatial memory spans than for verbal memory spans, replicating previous results.

Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study.

Objective: Few studies have assessed the role of specific gastrointestinal infections in celiac disease. We investigated whether increased frequency of rotavirus infection, a common cause of gastrointestinal infection and inflammation, predicts increased risk of celiac disease autoimmunity.

Methods: A cohort of 1,931 children from the Denver metropolitan area who carried celiac disease human leukocyte antigen (HLA) risk alleles were followed from infancy for development of celiac disease autoimmunity, defined as positivity at two or more subsequent clinic visits for tissue transglutaminase (tTG) autoantibodies measured using a radioimmunoassay with human recombinant tTG.

Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates.

Objective: Certain human leukocyte antigen (HLA)-DR,DQ genotypes have been associated with type 1 diabetes mellitus (T1DM) risk, although it is unknown whether the association is due to alleles, haplotypes, genotypes, the formation of heterodimers, or all of the above. To characterize the role of the HLA-DR,DQ genotype and ethnicity on the onset age of T1DM, we analyzed these factors in patients with T1DM and the general population.

Methods: One thousand three hundred twenty-two well-characterized patients with T1DM were compared with 3339 children from the general population of Denver, Colorado, USA.

Association of non-HLA genes with type 1 diabetes autoimmunity.

Approximately 50% of the genetic risk for type 1 diabetes is attributable to the HLA region. We evaluated associations between candidate genes outside the HLA region-INS, cytotoxic T-lymphocyte-associated antigen (CTLA)-4, interleukin (IL)-4, IL-4R, and IL-13 and islet autoimmunity among children participating in the Diabetes Autoimmunity Study in the Young (DAISY). Children with persistent islet autoantibody positivity (n = 102, 38 of whom have already developed diabetes) and control subjects (n = 198) were genotyped for single nucleotide polymorphisms (SNPs) in the candidate genes.

Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease.

Context: While gluten ingestion is responsible for the signs and symptoms of celiac disease, it is not known what factors are associated with initial appearance of the disease.

Objective: To examine whether the timing of gluten exposure in the infant diet was associated with the development of celiac disease autoimmunity (CDA).

Design, Setting, And Patients: Prospective observational study conducted in Denver, Colo, from 1994-2004 of 1560 children at increased risk for celiac disease or type 1 diabetes, as defined by possession of either HLA-DR3 or DR4 alleles, or having a first-degree relative with type 1 diabetes.

Secondary attack rate of type 1 diabetes in Colorado families.

Objective: Families of children diagnosed with type 1 diabetes require counseling concerning type 1 diabetes risk in nondiabetic siblings and parents. No U.S.