HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis.

Problem: The aim of this meta-analysis was to evaluate whether specific maternal HLA alleles and HLA sharing of couples are associated with the occurrence of recurrent miscarriage (RM).

Method Of Study: A systematic literature search was performed for studies that evaluated the association between HLA alleles, HLA sharing and RM. RM was defined as three or more consecutive unexplained miscarriages and a control group was included of women with at least one live birth and no miscarriages in their history.

[Pre-eclampsia as a complication of egg donation: a different pathophysiological mechanism?].

Egg donation (ED) enables infertile women to conceive. This results in a unique situation as the fetal genome is totally allogeneic to the mother. We discuss a 41-year-old woman whose pregnancy after ED was complicated by severe preeclampsia.