Determining a cutoff for fetal lung maturity with lamellar body count testing.

Objective: A lamellar body count (LBC) >or= 50,000/microl is suggested to document fetal lung maturity (FLM). We sought to determine the LBC threshold for FLM with the Cell-dyn 4000 hematology analyser.

Methods: We queried our database for patients who underwent LBC testing from 2001 to 2007.

Absent or shortened nasal bone length and the detection of Down Syndrome in second-trimester fetuses.

Objective: To estimate the accuracy of evaluating nasal bone length, expressed as multiples of the median (MoM), for the detection of Down syndrome in second- trimester fetuses.

Methods: Expected normal median nasal bone measurements were established for an initial cohort of women receiving fetal ultrasound examinations at 15-24 weeks of gestation. Nasal bone lengths were converted to MoM with adjustment for maternal race and ethnicity using whites as the referent group.