PsEma--a hitherto unnamed dermatologic entity with clinical features of both psoriasis and eczema.

Introduction: Recent advances in molecular biology have helped establish differences between psoriasis and a group of inflammatory skin disorders commonly referred to as eczema. The authors have observed significant overlap between these two conditions such that a distinction between them may not always be made, even with histologic examination of skin biopsy specimens.

Objective: To determine how frequently psoriasis patients present features of both psoriasis and eczema.

Atopic profiles, familial histories, and coexisting conditions associated with hand eczema.

Background: Many of the eczema cases seen by dermatologists involve the hands. The discomfort and embarrassment of hand dermatitis in any of its forms may compromise a patient's quality of life, causing frustrated attempts to identify the cause of the disease and engendering disappointment with treatment failures.

Methods: The authors assessed the severity scores for each patient, personal and familial histories of atopy, coexisting conditions, triggers of irritation, types of treatments, and their success rates.

Changing paradigms in dermatology: topical immunomodulators within a permutational paradigm for the treatment of atopic and eczematous dermatitis.

The first formulation of a class of products called topical immuno modulators (TIMS) was approved for clinical use in December 2000 and released in February 2001. This product is tacrolimus in an ointment base, prescribed under the Protopic. The next TIM, pimecrolimus cream, was FDA approved in December 2001 and launched February 2002 in a cream vehicle under the Elidel.

Changing paradigms in dermatology: new ways to examine the skin using noninvasive imaging methods.

Detailed visualization of the skin in the practice of dermatology is key to a comprehensive examination and accurate diagnosis. Advancements in digital dermoscopy, microscopy, imaging and photography have formed an impressive arsenal with which dermatologists can offer state-of-the-art patient care while streamlining their clinical practice and improving their academic and research capacities. Many types of advanced imaging are used in the biologic sciences at the bench; however, our paper reviews the clinical, noninvasive in vivo human applications of these emerging technologies.