Publications by authors named "Lisa Brunner"

Article Synopsis
  • There is a demand for new quick-acting treatments for affective disorders, particularly through the use of 3α-reduced neurosteroids like allopregnanolone, which enhance GABA receptor activity.
  • These neurosteroids are produced by the translocator protein 18 kDa (TSPO), which also influences mitochondrial function and has anti-inflammatory properties.
  • Recent developments show that TSPO ligands and 3α-reduced neurosteroids, including etifoxine and brexanolone, could offer promising treatment options for conditions like depression and anxiety.
View Article and Find Full Text PDF

Introduction: Peripheral artery disease (PAD) is the third most prevalent cardiovascular disease worldwide, with smoking and diabetes being the strongest risk factors. The most prominent symptom is leg pain while walking, known as intermittent claudication. To improve mobility, first-line treatment for intermittent claudication is supervised exercise programmes, but these remain largely unavailable and economically impractical, which has led to the development of structured home-based exercise programmes.

View Article and Find Full Text PDF