Publications by authors named "Lisa Barros de Andrade E Sousa"
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Synopsis of recent research by authors named "Lisa Barros de Andrade E Sousa"
Recent research by Lisa Barros de Andrade E Sousa focuses on enhancing predictive models and analysis techniques in genomic and epigenomic studies, particularly within bacterial CRISPR technology and DNA methylation.
One significant finding involves the development of a mixed-effect random forest regression model that improves the prediction accuracy of CRISPR interference guide efficiency based on gene-specific characteristics, addressing previously poorly defined design rules.
Additionally, her work includes a systematic evaluation of cell-type deconvolution methods for interpreting bulk DNA methylomes, highlighting the potential for better understanding cell-type heterogeneity in genomics.
