Aerobic Exercise Induces Functional and Structural Reorganization of CNS Networks in Multiple Sclerosis: A Randomized Controlled Trial.

: Evidence from animal studies suggests that aerobic exercise may promote neuroplasticity and could, therefore, provide therapeutic benefits for neurological diseases such as multiple sclerosis (MS). However, the effects of exercise in human CNS disorders on the topology of brain networks, which might serve as an outcome at the interface between biology and clinical performance, remain poorly understood. : We investigated functional and structural networks in patients with relapsing-remitting MS in a clinical trial of standardized aerobic exercise.

Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis-a randomized controlled trial.

Background: Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis.

Objective And Methods: This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.