MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.

Taking the structural information into account, we were able to tune the TEAD selectivity for a specific chemotype. However, different TEAD selectivity profiles did not affect the compound potency or efficacy in the NCI-H226 viability assay. Amides based on or analogues showed improved viability efficacy compared with the corresponding acids.

Establishing partnerships to recruit and retain critical care nurses.

The current need to increase numbers of critical care nurses presents an exciting opportunity for nurses in staff development. Partnerships forged between university faculty and nurses have potential to recruit students into critical care settings. This article describes a course taught by faculty and practicing nurses that encourages students to pursue careers in critical care.

Long-term developmental, behavioral, and attachment outcomes after international adoption.

Children adopted internationally and their families are a heterogeneous group. Internationally-adopted children have been reported to have a range of developmental and behavioral difficulties. The authors describe the current evidence documenting developmental outcomes for children and common behavioral and mental health concerns including attachment difficulties that may impact children and their families after international adoption.