Publications by authors named "Lisa A Krattiger"
Article Synopsis
- Researchers are developing a new method to study anti-angiogenic therapies (AATs) by creating complex 3D micro-capillary networks using human cells.
- These engineered networks can be used to observe how blood vessels react to treatment with drugs like bevacizumab and how they regrow once the treatment stops.
- The goal of this new platform is to better understand the mechanisms behind resistance to AATs and to improve drug screening for conditions like cancer and diabetic retinopathy.
The bone and bone marrow are highly vascularized and structurally complex organs, and are sites for cancer and metastasis formation. In vitro models recapitulating bone- and bone marrow-specific functions, including vascularization, that are compatible with drug screening are highly desirable. Such models can bridge the gap between simplistic, structurally irrelevant two-dimensional (2D) in vitro models and the more expensive, ethically challenging in vivo models.
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