Publications by authors named "Lisa A Huang"
Article Synopsis
- The study examines how small nucleolar RNAs (snoRNAs), particularly SNORD46, are linked to obesity and its related cancer risks.
- Researchers found that serum levels of SNORD46 correlate with body mass index (BMI) and that this snoRNA interferes with interleukin-15 (IL-15) signaling, which is crucial in energy metabolism.
- SNORD46's ability to inhibit specific pathways in both adipocytes and natural killer (NK) cells contributes to obesity and reduced immune response, suggesting that snoRNA inhibitors could be beneficial for tackling obesity and enhancing cancer treatments.
Next-generation sequencing has revealed that less than 2% of transcribed genes are translated into proteins, with a large portion transcribed into noncoding RNAs (ncRNAs). Among these, long noncoding RNAs (lncRNAs) represent the largest group and are pervasively transcribed throughout the genome. Dysfunctions in lncRNAs have been found in various diseases, highlighting their potential as therapeutic, diagnostic, and prognostic targets.
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- PDAC, or pancreatic ductal adenocarcinoma, faces treatment challenges due to its immune-resistant environment, particularly influenced by tumor-associated nonmyelinating Schwann cells (TASc).
- Research found that higher levels of TASc are linked to immune suppression and poorer patient outcomes, and removing these cells can actually boost tumor growth.
- Additionally, a specific long noncoding RNA related to TASc, activated by interleukin-6 from tumor cells, plays a critical role in altering enzymatic processes that aid PDAC progression, making TASc a potential target for improving immunotherapy effectiveness.
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti-programmed cell death 1 and anti-cytotoxic T lymphocyte antigen-4 antibodies but also presented with cardiovascular toxicities observed clinically with ICI therapy, including myocarditis and arrhythmia. Female mice were preferentially affected with myocarditis compared to male mice, consistent with a previously described genetic model of ICI myocarditis and emerging clinical data.
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