Publications by authors named "Lirui Tu"
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressive infectious disease triggered by a novel bunyavirus (SFTSV). Despite the critical role of host lipid metabolism in viral infections, research on dyslipidemia in SFTS remains limited.
Methods: This retrospective study included 433 SFTS patients, who were stratified into survival group (n = 365) and death group (n = 68) and who were treated at the Shandong Public Health Clinical Center from September 2021 to December 2023.
Article Synopsis
- Severe fever with thrombocytopenia syndrome (SFTS) is a serious infectious disease linked to a novel bunyavirus, and this study focuses on understanding how lipid metabolism changes during early SFTSV infection.
- The researchers collected blood samples from patients with severe and mild SFTS, as well as healthy controls, to analyze lipid differences and correlations with clinical outcomes.
- The results show significant dysregulation of lipids in SFTS patients, with notable increases and decreases in specific lipids compared to healthy individuals, shedding light on potential mechanisms and paving the way for improved diagnosis and treatment options.
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease triggered by a novel bunyavirus (SFTSV). Characterized by fever, thrombocytopenia, leukocytopenia, and multiple organ dysfunction manifestations, its primary mode of transmission is through tick bites. Despite the critical role of lipid metabolism in viral infections, the role of lipids in SFTS remains unclear.
View Article and Find Full Text PDFSevere fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever with high mortality. Severe cases progressed rapidly, with deaths occurring within 2 weeks. Therefore, constructing a model to predict disease progression among hospitalized patients plays an important role in clinical practice.
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