A case report of a newborn who underwent ultra-high enterostomy and intestinal fluid return after necrosis of intestinal volvulus.

Background: Neonatal intestinal malrotation complicated by midgut volvulus is a serious and common life-threatening complication. When the midgut volvulus is prolonged or severe, it can lead to secondary necrosis of the entire midgut, with high mortality rates. Therefore, improving understanding the clinical characteristics of this condition is necessary to facilitate early diagnosis and treatment.

Relationship between infant gastrointestinal microorganisms and maternal microbiome within 6 months of delivery.

To investigate the association between the microbiota in mothers and gut microbiota in infants from 0 to 6 months, the microbiotas in infant feces, maternal feces, and breast milk were determined by 16S rRNA gene sequencing. The contribution of each maternal microbiome to the infant was assessed using fast expectation-maximization for microbial source tracking calculations. The levels of short-chain fatty acids (SCFAs) and secretory immunoglobulin A (sIgA) in the feces of infants were also determined using gas chromatography and IDK-sIgA ELISA to gain a more comprehensive understanding of the infant gut microbiome.

The lactate dehydrogenase gene is involved in the growth and metabolism of and the production of fermented milk flavor substances.

Objective: Lactate dehydrogenase (ldh) in lactic acid bacteria is an important enzyme that is involved in the process of milk fermentation. This study aimed to explore the changes and effects of fermented milk metabolites in mutant strains after knocking out the gene of .

Methods: The mutant Δ was obtained from using clustered regularly interspaced short palindromic repeats technology, and we determined fermented milk pH, titratable acidity, viable count, and differential metabolites in the different stages of milk fermentation that were identified using metabolomic analysis.

A newborn with coffin-siris syndrome.

Coffin-Siris syndrome (CSS) is a rare congenital genetic syndrome, a multisystem disease related to congenital abnormalities, that manifests with abnormal features, causes repeated infections and is associated with developmental delays. Here, we report a newborn male with CSS from Baoding in the Hebei Province of China.

In vitro Intervention of Lactobacillus paracasei N1115 Can Alter Fecal Microbiota and Their SCFAs Metabolism of Pregnant Women with Constipation and Diarrhea.

In vitro fermentation was used to evaluate the possible effects of intervention with Lactobacillus paracasei N1115 (LP N1115) on gut microbiota and metabolite shortchain fatty acids (SCFAs) in pregnant women with constipation and diarrhea. Feces were collected from pregnant women and fermented by YCFA medium to profile the changes in the gut microbiota before and after intervention with LP N1115 using 16SrRNA sequencing. At the same time, the changes in several specific bacteria were detected using quantitative real-time PCR (qPCR) and the SCFAs in fermentation were detected using gas chromatography (GC) for each subject to determine the effect of the intervention.

Detection of viable Lacticaseibacillus paracasei in fermented milk using propidium monoazide combined with quantitative loop-mediated isothermal amplification.

To quantify viable probiotic Lacticaseibacillus paracasei (L. paracasei) in fermented milk accurately and quickly, propidium monoazide combined with quantitative loop-mediated isothermal amplification (PMA-qLAMP) was applied. The optimal PMA treatment conditions for treating a L.

Composition Optimization and Microstructure Design in MOFs-Derived Magnetic Carbon-Based Microwave Absorbers: A Review.

Magnetic carbon-based composites are the most attractive candidates for electromagnetic (EM) absorption because they can terminate the propagation of surplus EM waves in space by interacting with both electric and magnetic branches. Metal-organic frameworks (MOFs) have demonstrated their great potential as sacrificing precursors of magnetic metals/carbon composites, because they provide a good platform to achieve high dispersion of magnetic nanoparticles in carbon matrix. Nevertheless, the chemical composition and microstructure of these composites are always highly dependent on their precursors and cannot promise an optimal EM state favorable for EM absorption, which more or less discount the superiority of MOFs-derived strategy.

Space-Confined Synthesis of Core-Shell BaTiO@Carbon Microspheres as a High-Performance Binary Dielectric System for Microwave Absorption.

Binary dielectric composites are viewed as a kind of promising candidate for conventional magnetic materials in the field of microwave absorption. Herein, we demonstrate the successful fabrication of core-shell BaTiO@carbon microspheres through a space-confined strategy. The electromagnetic properties of BaTiO@carbon microspheres can be easily tailored by manipulating the relative content of carbon shells.

NIR light responsive core-shell nanocontainers for drug delivery.

A novel near infrared (NIR)-triggered anticancer drug delivery system has been successfully constructed. Firstly, upconversion nanoparticles (UCNPs, NaYF:Tm,Yb@NaYF) were synthesized as a core and mesoporous silica (mSiO) as a shell to assemble the core-shell nanostructure (UCNP@mSiO) as the host. Supramolecular nanovalves based on α-cyclodextrin (α-CD) torus encircling a pimelic acid thread and being held in place by a cleavable stopper (nitrobenzyl alcohol) were used as nanoscopic caps to block the pore and inhibit drug diffusion.

FeO@mSiO core-shell nanocomposite capped with disulfide gatekeepers for enzyme-sensitive controlled release of anti-cancer drugs.

Multifunctional nanocarriers based on the magnetic FeO nanoparticle core and bis-(3-carboxy-4-hydroxy phenyl) disulfide (R-S-S-R) modified mesoporous silica shell (FeO@mSiO@R-S-S-R) were synthesized for cancer treatment through passive targeting and enzyme-sensitive drug release. Anti-cancer drug doxorubicin (DOX) was used as the model cargo to reveal the release behavior of the system. The drug loading system (DOX-FeO@mSiO@R-S-S-R) retains the drug until it reaches the tumor tissue where glutathione reductase (GSH) can degrade the disulfide bonds and release the drug.

Simple way to obtain pH-sensitive drug release from functional mesoporous silica materials.

A novel pH-sensitive drug release system has been synthesised by functional mesoporous silica materials. SBA-15, calcium modified SBA-15 (Ca-SBA-15) and phosphate modified SBA-15 (PO4-SBA-15) were synthesised using solvent evaporation method. It is a simple and feasible way to prepare the doping mesoporous silica materials.

pH-responsive magnetic core-shell nanocomposites for drug delivery.

Polymer-modified nanoparticles, which can load anticancer drugs such as doxorubicin (DOX), showing the release in response to a specific trigger, have been paid much attention in cancer therapy. In our study, a pH-sensitive drug-delivery system consisting of Fe3O4@mSiO2 core-shell nanocomposite (about 65 nm) and a β-thiopropionate-poly(ethylene glycol) "gatekeeper" (P2) has been successfully synthesized as a drug carrier (Fe3O4@mSiO2@P2). Because of the hydrolysis of the β-thiopropionate linker under mildly acidic conditions, Fe3O4@mSiO2@P2 shows a pH-sensitive release performance based on the slight difference between a tumor (weakly acid) and normal tissue (weakly alkaline).

pH-responsive controlled-release system based on mesoporous bioglass materials capped with mineralized hydroxyapatite.

A controlled release system with pH-responsive ability has been presented. Mesoporous bioglass (MBG) was used as the drug carrier and a spontaneous mineralization method was adopted to cap the pores of the carrier with hydroxyapatite (HAp) and to restrict the drug release. It is a simple and green method to realize the ingenious pH-sensitive controlled release.

An enzyme-responsive controlled release system of mesoporous silica coated with Konjac oligosaccharide.

A simple and green method to fabricate an ingenious enzyme-responsive drug controlled release system was presented. Mesoporous silica material (mSiO2) 100 nm in size was used as the host, and Konjac oligosaccharide (KOGC) was employed to seal the nanopores of mSiO2 to inhibit the drug release. Rhodamine B was used as the model cargo to reveal the release behavior of the system.