Publications by authors named "Lirane Bitton"
The antibody immune response is essential for the survival of mammals. However, we still lack a systematic understanding of the antibody repertoire. Here, we developed a proteomic strategy to survey, at an unprecedented scale, the landscape of antigen-engaged, circulating camelid heavy-chain antibodies, whose minimal binding fragments are called VH antibodies or nanobodies.
View Article and Find Full Text PDFArticle Synopsis
- The CAPRI Round 46 involved 20 protein assembly targets, blending 14 homo-oligomers with 6 heterocomplexes, highlighting challenges in modeling.
- A significant number of models (~2000 per target) were submitted by about 30 teams, with better performance seen in easier targets but struggles with complex compositions, as evidenced by only 3 out of 11 difficult targets yielding medium to high-quality models.
- Analysis revealed a decline in prediction quality for binding interface residues compared to previous rounds, pointing to areas needing improvement for future challenges.