The Critical Role of Phenylpropanoid Biosynthesis Pathway in Lily Resistance Against Gray Mold.

Gray mold caused by is one of the most determinative factors of lily growth and has become a major threat to lily productivity. However, the nature of the lily interaction remains largely unknown. Here, comparative transcriptomic and metabolomic were used to investigate the defense responses of resistant ('Sorbonne') and susceptible ('Tresor') lily cultivars to infection at 24 hpi.

Biochemical and transcriptomic analyses reveal that critical genes involved in pigment biosynthesis influence leaf color changes in a new sweet osmanthus cultivar 'Qiannan Guifei'.

Background: (Oleaceae) is one of the most important ornamental plant species in China. Many cultivars with different leaf color phenotypes and good ornamental value have recently been developed. For example, a new cultivar 'Qiannan Guifei', presents a rich variety of leaf colors, which change from red to yellow-green and ultimately to green as leaves develop, making this cultivar valuable for landscaping.

Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.

DNA transfection is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the role of the cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion of cGAS enhances transgene expression at the protein level by ~2- to 3-fold.

A modified method for reducing renal injury in zoledronic Acid treatment of hypercalcemia and adverse skeletal events.

Aims: In this paper, we have reported a previously undescribed risk factor of deterioration of renal function in zoledronic acid treatment of skeletal metastasis - high serum calcium level. Based on this consideration, a modified method of treatment of hypercalcemia (HCM) with zoledronic acid is suggested in this paper.

Material And Methods: Bone scan findings of 1090 cancer patients were analyzed, of which 26 had intense renal parenchymal uptake as a result of HCM or bone metastases.

6-(2-Fluoro-phen-yl)-5,6-dihydro-benzimidazolo[1,2-c]quinazoline.

In the title compound, C(20)H(14)FN(3), the pyrimidine ring adopts a half-chair conformation. The dihedral angle between the benzimidazole ring system and the fluoro-phenyl ring is 84.18 (10)°.