Chitin and its deacetylated form, chitosan, have demonstrated remarkable versatility in the realm of biomaterials. Their exceptional biocompatibility, antibacterial properties, pro- and anticoagulant characteristics, robust antioxidant capacity, and anti-inflammatory potential make them highly sought-after in various applications. This review delves into the mechanisms underlying chitin/chitosan's biological activity and provides a comprehensive overview of their derivatives in fields such as tissue engineering, hemostasis, wound healing, drug delivery, and hemoperfusion.
View Article and Find Full Text PDFAlthough protein subunit vaccines generally have acceptable safety profiles with precise antigenic content, limited immunogenicity can lead to unsatisfactory humoral and cellular immunity and the need for vaccine adjuvants and delivery system. Herein, we assess a vaccine adjuvant system comprising Quillaja Saponaria-21(QS-21) and cobalt porphyrin polymeric micelles that enabling the display of His-tagged antigen on its surface. The nanoscale micelles promote antigen uptake and dendritic cell activation to induce robust cytotoxic T lymphocyte response and germinal center formation.
View Article and Find Full Text PDFmessenger RNA (mRNA) vaccines are a key technology in combating existing and emerging infectious diseases. However, the inherent instability of mRNA and the nonspecificity of lipid nanoparticle-encapsulated (LNP) delivery systems result in the need for cold storage and a relatively short-duration immune response to mRNA vaccines. Herein, we develop a novel vaccine in the form of circRNAs encapsulated in LNPs, and the circular structure of the circRNAs enhances their stability.
View Article and Find Full Text PDFIt is technically challenging to reversibly tune the layer number of 2D materials in the solution. Herein, a facile concentration modulation strategy is demonstrated to reversibly tailor the aggregation state of 2D ZnIn S (ZIS) atomic layers, and they are implemented for effective photocatalytic hydrogen (H ) evolution. By adjusting the colloidal concentration of ZIS (ZIS-X, X = 0.
View Article and Find Full Text PDFBackground: Plants in the genus Artemisia are rich in active ingredients and specialized metabolites. Many of these compounds, especially flavonoids, have potential medicinal and nutritional applications, and are of growing interest to scientists due to their wide range of pharmacological and biological activities. Artemisia cultivars are commonly used as raw materials for medicine, food, and moxibustion in China.
View Article and Find Full Text PDFACS Appl Mater Interfaces
June 2023
The performance of the blue perovskite light-emitting diodes (PeLEDs) is limited by the low photoluminescence quantum yields (PLQYs) and the unstable emission centers. In this work, we incorporate sodium bromide and acesulfame potassium into a quasi-2D perovskite to control the dimension distribution and promote the PLQYs. Benefiting from the efficient energy cascade channel and passivation, the sky-blue PeLED has an external quantum efficiency of 9.
View Article and Find Full Text PDFAnthropogenic activities have caused environmental metal contamination in urban areas. Biomonitoring using organisms such as invertebrates can evaluate metal pollution, supplementing chemical monitoring, which cannot comprehensively reflect how metals influence organisms in the urban environment. To assess metal contamination in Guangzhou urban parks and its source, Asian tramp snails (Bradybaena similaris) were collected from ten parks in Guangzhou in 2021.
View Article and Find Full Text PDFSlow charge kinetics and unfavorable CO adsorption/activation strongly inhibit CO photoreduction. In this study, a strain-engineered Cs Bi Br /hierarchically porous BiVO (s-CBB/HP-BVO) heterojunction with improved charge separation and tailored CO adsorption/activation capability is developed. Density functional theory calculations suggest that the presence of tensile strain in Cs Bi Br can significantly downshift the p-band center of the active Bi atoms, which enhances the adsorption/activation of inert CO .
View Article and Find Full Text PDFIntroduction: is a ubiquitous foodborne pathogen and mainly transmitted to human farm-to-fork chain through contaminated foods of animal origin.
Methods: In this study, we investigated the serotypes, antimicrobial resistance and virulence of from China.
Results: A total of 617 isolates were collected from 4 major food animal species across 23 provi nces in China from 2015-2021.
Obstructive jaundice is a common clinical symptom generally caused by bile duct stones, inflammatory hyperplasia, and tumors. It is characterized by hyperbilirubinemia and may trigger a variety of complications such as hypotension, kidney injury, endotoxemia, multiple organ dysfunction syndrome, and even death (Pavlidis and Pavlidis, 2018; Liu et al., 2021).
View Article and Find Full Text PDFBiomass ethanol is regarded as a renewable resource but it is not economically viable to transform it to high-value industrial chemicals at present. Herein, a simple, green, and low-cost CuCl-ethanol complex is reported for ethanol dehydration to produce ethylene and acetal simultaneously with high selectivity under sunlight irradiation. Under N atmosphere, the generation rates of ethylene and acetal were 165 and 3672 μmol g h, accounting for 100% in gas products and 97% in liquid products, respectively.
View Article and Find Full Text PDFPostoperative peritoneal adhesions are common complications caused by abdominal and pelvic surgery, which seriously impact the quality of life of patients and impose additional financial burdens. Using of biomedical materials as physical barriers to completely isolate the traumatic organ and injured tissue is an optimal strategy for preventing postoperative adhesions. However, the limited efficacy and difficulties in the complete degradation or integration of biomedical materials with living tissues restrict the application of these materials.
View Article and Find Full Text PDFFor coal and gangue, intelligent sorting processes for separation, the use of coal and gangue mineral components with different fundamental differences, and the study of different properties of minerals and coal with different scales and density regarding the gray value change law are presented. The results show that the gray value of single minerals and mixed minerals gradually decreases with the increase of their thickness and density. The greater the density of minerals, the smaller the gray value at the same thickness, and the same rule applies to different coal ranks.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2023
Purpose: Acute lung injury (ALI) is a fatal acute inflammatory illness with restricted therapeutic choices clinically. Piperlongumine (PL) is recognized as an alkaloid separated from Piper longum L, which was suggested to exhibit multiple pharmacological activities (e.g.
View Article and Find Full Text PDFDrug-induced liver and kidney damage is an emergent clinical issue that should be addressed. Rosmarinic acid (RA) has obvious anti-inflammatory and antioxidant effects, so we evaluated the anti-inflammatory and antioxidant effects of RA pretreatment on serum and liver and kidney tissues of cisplatin (CP)-treated mice and explored the possible mechanisms. The results showed that RA pretreatment effectively downregulated the serum, liver, and kidney levels of ALT, AST, BUN, and CRE and the inflammatory factors IL-1β, IL-6, and TNF-α, and simultaneously enhanced the total antioxidant capacity of the liver and kidney.
View Article and Find Full Text PDFThe clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water solubility, unstable absorption, and low bioavailability. Solid lipid nanoparticles (SLNs) exhibit high biocompatibility and the ability to improve the bioavailability of drugs with low water solubility. Therefore, in this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared by a hot melt-emulsification ultrasonication method to improve the sustained release and bioavailability of TA.
View Article and Find Full Text PDFNasopharyngeal carcinoma (NPC), featured by Epstein-Barr virus (EBV) infection and regional epidemiology, is curable when detected early, but highly lethal at an advanced stage. The molecular mechanism of NPC progression toward a clinically uncontrollable stage remains elusive. In this study, we developed a novel computational framework to conduct multiscale transcriptomic analysis during NPC progression.
View Article and Find Full Text PDFPeople spend increasing amounts of time at home, yet the indoor home environment remains understudied in terms of potential exposure to toxic trace metals. We evaluated trace metal (and metalloid) concentrations (As, Cu, Cr, Mn, Ni, Pb, and Zn) and health risks in indoor dust from homes from 35 countries, along with a suite of potentially contributory residential characteristics. The objective was to determine trace metal source inputs and home environment conditions associated with increasing exposure risk across a range of international communities.
View Article and Find Full Text PDFAntibiotic resistance is an increasing concern for human and animal health worldwide. Recently, the concept of reverting bacterial resistance by changing the metabolic state of antibiotic-resistant bacteria has emerged. In this study, we investigated the reversal of Apramycin resistance in .
View Article and Find Full Text PDFThis study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subsequently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate succinate (HPMCAS)-LG was the carrier of pure PZQ, with a standard screw configuration used at an extrusion temperature of 140 °C and a screw rotation speed of 100 rpm. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR) were performed to characterize the extrudate.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
August 2021
Leaf mass per area (LMA) is an important parameter in the construction of the ecosystem process models. Accurate prediction of the dynamic validation of canopy LMA is of significance to improve the accuracy of ecosystem process models. We conducted vertical whorl-by-whorl sampling and analyzed LMA in different seasons for plantation in Maoershan in Shangzhi, Heilongjiang Province, China.
View Article and Find Full Text PDFFlunixin meglumine (FM) is a nonsteroidal anti-inflammatory drug limited by irritation of the respiratory tract and mucosa in veterinary tissue. This study aimed to develop a taste-masked FM solid dispersion (SD) by hot-melt extrusion (HME) and formulate an orally disintegrating tablet (ODT) with selected excipients by direct compression. Eudragit® E PO was chosen as the matrix, and HME parameters were optimized: extrusion temperature, 135℃; screw speed, 100 rpm; and drug loading, 20%.
View Article and Find Full Text PDFComput Intell Neurosci
August 2021
Deep learning and neural network have been widely used in the field of speech, vocabulary, text, pictures, and other information processing fields, which has achieved excellent research results. Neural network algorithm and prediction model were used in this paper for the study and exploration of English grammar. Aiming at the application requirements of English grammar accuracy and standardization, we proposed a machine learning model based on LSTM-CRF to detect and analyze English grammar.
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