5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosis.

Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) play a crucial role in sorafenib resistance in hepatocellular carcinoma (HCC), and lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a dysregulated lncRNA in sorafenib-resistant HCC cells. However, the underlying regulatory mechanisms of MALAT1 in sorafenib-resistant HCC cells remain unclear. In the present study, we demonstrated that 5-methylcytosine (mC) methylation catalyzed by NSUN2 and ALYREF contributed to the RNA stability and upregulation of MALAT1.

LincROR promotes tumor growth of colorectal cancer through the miR-145/WNT2B/WNT10A/Wnt/β-catenin regulatory axis.

Colorectal cancer (CRC) is a prevalent form of malignant tumor, and the current clinical treatments are far from satisfactory. Identifying new therapeutic targets is therefore essential for clinical practices. The long intergenic non-protein coding RNA lincROR has been shown to play a significant role in the tumorigenesis of various cancers.

EIF4A3-negatively driven circular RNA β-catenin (circβ-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis.

Background: Circβ-catenin, our first reported circRNA, has been reported to mediate tumorigenesis in various cancers. However, its biological functions and underlying mechanisms in colorectal cancer (CRC) remain unknown.

Methods: The qRT-PCR examination was used to detect the expression of circβ-catenin, miR-197-3p, and CTNND1 in cells and human tissues.

Preparation and research of PCL/cellulose composites: Cellulose derived from agricultural wastes.

For the rational use of agricultural wastes, bagasse, orange peel and wheat bran were used to fabricate bio-based polymer materials. Cellulose was extracted from the three different agricultural wastes, and poly(ε-caprolactone) (PCL) was used as the matrix material. PCL was mixed with nanocrystalline cellulose (CNC), extracted bagasse cellulose (GC), orange peel cellulose (JC) and wheat bran cellulose (MC) by solution casting.

LncRNA-NEF suppressed oxaliplatin resistance and epithelial-mesenchymal transition in colorectal cancer through epigenetically inactivating MEK/ERK signaling.

A major cause of oxaliplatin chemoresistance in colorectal cancer (CRC) is acquired epithelial-mesenchymal transition (EMT) in cancer cells, making the cancer cells easy to metastasis and recurrence. LncRNA Neighboring Enhancer of FOXA2 (lncRNA-NEF) has been characterized as a tumor suppressor to mediate cancer metastasis in multiple cancer types. However, whether it mediated the drug resistance remains unknown.

Linc-ROR drive adriamycin resistance by targeting AP-2α/Wnt/β-catenin axis in hepatocellular carcinoma.

Adriamycin is widely used as a chemotherapeutic strategy for advanced hepatocellular carcinoma (HCC). However, the clinical response was disappointing because of the acquired drug resistance with long-term usage. Revealing the underlying mechanism could provide promising therapeutics for the drug-resistant patients.

Enhances Nasopharyngeal Carcinoma Cell Radiosensitivity the //Signal Transducer and Activator of Transcription-1/Forkhead Box O-1 Axis.

Nasopharyngeal carcinoma (NPC) is a common malignancy of the nasopharynx, and radioresistant represents the main obstacle in NPC treatment. Malignant transformation of normal cells is driven by genetic and epigenetic changes, which are primarily manifested as changes in miRNA levels and DNA methylation status. microRNA (miR)-613 plays an inhibitory role in several types of cancer.

Icariside II suppressed tumorigenesis by epigenetically regulating the circβ-catenin-Wnt/β-catenin axis in colorectal cancer.

Icariside II, a flavonol glycoside, one of the major components of Traditional Chinese Medicine Herba epimedii. In the present study, we found that Icariside II suppressed the proliferation of CRC by inducing cell cycle arrest and apoptosis in vitro and inhibited tumor growth in vivo. The further mechanism investigation showed that Icariside II suppressed the expression of β-catenin and led to the functional inactivation of Wnt/β-catenin signaling.

An effective strategy for improving charge separation efficiency and photocatalytic degradation performance using a facilely synthesized oxidative TiO catalyst.

Titanium dioxide (TiO) has attracted enormous interest in abundant photocatalytic reactions, but its photocatalytic efficiency is limited by its wide bandgap and the rapid recombination of electron-hole pairs. To overcome the disadvantages of its rapid electron-hole recombination rate, herein, oxidative TiO was one-step fabricated using potassium permanganate (KMnO), exhibiting improved charge separation efficiency and photocatalytic degradation performance towards methyl orange (MO). Remarkably, the first-order photodegradation rate of oxidative TiO is 3.

Sufentanil Inhibits the Proliferation and Metastasis of Esophageal Cancer by Inhibiting the NF-B and Snail Signaling Pathways.

Sufentanil is a -opioid receptor agonist, widely used in intraoperative and postoperative analgesia of esophageal cancer. This study investigated the effects of sufentanil on the proliferation, invasion, and metastasis of esophageal carcinoma cells and its molecular mechanisms. Human esophageal carcinoma cells CaES-17 and Eca-109 were cultured in vitro.

Quantifying the contributions of human activities and climate change to vegetation net primary productivity dynamics in China from 2001 to 2016.

Vegetation is an important component of the terrestrial ecosystem, driven by climate change and human activities. Quantifying the relative contributions of climate change and anthropogenic activities to vegetation dynamics are essential to cope with global climate change. In this paper, the relative contributions of anthropogenic activities and climate change to net primary productivity (NPP) in China were analyzed by a two-step methodology based on the residual trend analysis (RESTREND).

RNA N-methyladenosine modification is required for miR-98/MYCN axis-mediated inhibition of neuroblastoma progression.

Neuroblastoma (NB) is one of the most common malignant tumors of the sympathetic nervous system in childhood. NB severely threatens patient's health and life. However, more effective diagnosis and treatment methods are badly needed in clinics all over the world.

Improving glucose metabolism in the auditory cortex delays the aging of auditory function of guinea pig.

The glucose homeostasis is essential for brain function, and energy deficiency is a key feature of brain aging. We investigated whether improving glucose metabolism in the auditory cortex can delay the aging of auditory function of guinea pigs with age-related hearing loss (ARHL) by d-galactose. Auditory function was assessed by auditory brainstem response (ABR), glucose metabolism was detected by micro PET/CT, and the proteome were identified in auditory cortex by two-dimensional electrophoresis and matrix assisted laser desorption/ionization mass spectrometry.

[Effect of Electroacupuncture on Expression of Catechol-O-methyltransferase in the Inferior Colliculus and Auditory Cortex in Age-related Hearing Loss Guinea Pigs].

Objective: To observe the expression of catechol-O-methyltransferase (COMT) in inferior colliculus and auditory cortex of guinea pigs with age-related hearing loss(AHL) induced by D-galactose, so as to explore the possible mechanism of electroacupuncture(EA) underlying preventing AHL.

Methods: Thirty 3-month-old guinea pigs were randomly divided into control group, model group and EA group(=10 in each group), and ten 18-month-old guinea pigs were allocated as elderly group. The AHL model was established by subcutaneous injection of D-galactose.

[Runoff and sediment yielding processes on red soil engineering accumulation containing gravels by a simulated rainfall experiment].

Engineering accumulation formed in production and construction projects is characterized by unique structure and complex material composition. Characteristics of soil erosion on the engineering accumulation significantly differ from those on farmland. An artificially simulated rainfall experiment was carried out to investigate the effects of rainfall intensity on the processes of runoff and sediment yielding on the engineering accumulation of different gravel contents (0%, 10%, 20% and 30%) in red soil regions.

Mechanism and symmetry properties of depolarization in weak scattering of light.

The mechanism and some symmetry properties of depolarization upon weak scattering of light from a class of random media were studied theoretically. Departing from the angular distribution of the degree of polarization, our derivations showed the mechanism that induces the change of polarization can be split into two parts of different nature. One is the vectorial effect that redistributes the original light components, and the other is the interaction effect of the medium that modulates the correlation properties of the incident field.