Publications by authors named "Lippincott B"

Growing evidence demonstrates that people with disabilities face more challenges in accessing healthcare and wellness resources, compared to non-disabled populations. As mobile applications focused on health and wellness (mHealth apps) become prevalent, it is important that people with disabilities can access and use mHealth apps. At present, there is no source of unified information about the accessibility and usability of mHealth apps for people with disabilities.

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Accessibility of telecommunication technologies by people who are deaf or hard of hearing has been a critical issue since the invention of the telephone. As both telephone and hearing-aid technologies have evolved, finding compatible solutions has been an ongoing challenge. This paper uses the findings of a longitudinal study to examine the impact of Federal hearing-aid compatibility (HAC) regulations in resolving this problem.

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Keloids are associated with small-fiber neuropathy and typically present with itching, pain, and allodynia. The following is a case presentation in which painful neuropathic symptoms from a keloid were treated successfully with botulinum toxin type A. To our knowledge, this is the first such case report in the literature.

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In 1986 Coleman developed the Owl and Lark Questionnaire to differentiate morning people from evening people, with owl individuals being more alert during the evening phase and lark individuals being more alert during the morning phase. Rossi has hypothesized that the bimodal peaks of hypnotizability found by Aldrich and Bernstein in 1987 were caused by alterations in owl and lark circadian rhythms. In the current study I used the Harvard Group Scale of Hypnotic Susceptibility, Form A to test compliance with hypnotic suggestions among 42 graduate students at three times of the day: in the morning, in the evening, and, as a control, in the middle of the night.

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Crown-gall tumor initiation by Agrobacterium tumefaciens is inhibited by cell walls from normal dicotyledonous plants but not by cell walls from crown-gall tumors apparently because of bacterial adherence or nonadherence, respectively, to the different cell walls. Cell walls from normal and tumor tissues in culture also show this difference, indicating that the two types of tissue stably maintain this difference under these conditions. Habituated tissue cultures, which resemble crown-gall tumor cultures, however, form cell walls that are inhibitory like those of the normal cultures from which they are derived.

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Avirulent strains IIBNV6 and NT1, derived from virulent strains of Agrobacterium tumefaciens, were tested for their ability to enhance tumor initiation (complement) on coinoculation with tumorigenic strains. Strain NT1, cured of the Agrobacterium virulence plasmid, failed to complement when inoculated with its virulent parental strain or with other virulent strains. Strain IIBNV6, however, complemented with all virulent strains tested.

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Cell wall preparations from primary bean leaves were found to inhibit tumor initiation by Agrobacterium tumefaciens strain B6 when inoculated with the bacteria on bean leaves. Membrane fractions from these same leaves were noninhibitory. The cell walls were effective when applied prior to or with bacteria, but application of cell walls about 15 minutes after bacteria did not affect the number of tumors initiated.

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Lipopolysaccharide (LPS) isolated from Agrobacterium tumefaciens inhibited tumor induction by virulent bacteria. LPS from site-binding strains was not effective if added to the plant wound shortly after the bacteria, and LPS from avirulent, non-site-binding strains of Agrobacterium was not inhibitory regardless of the order of addition. However, LPS and whole cells of avirulent strains NT1 and IIBNV6, which lack of Agrobacterim virulence plasmid, were inhibitory.

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Bean leaf tumors induced by Agrobacterium tumefaciens strain 181 show enhanced growth in response to octopine or lysopine only if one of these compounds is present during the period of tumor induction. Either compound applied during this period results in tumors which subsequently respond to both. The combined action of the bacterium plus octopine or lysopine at induction is proposed to induce transcription of plant genes coding for enzymes involved in the degradation and/or biosynthesis of octopine and lysopine.

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Tests for utilization of d-octopine and nopaline in defined media containing a carbon and nitrogen source were made on 60 strains of Agrobacterium representing four species and on a representative of each of five species of Rhizobium. Among 46 virulent strains of Agrobacterium, only two strains were found which utilized neither compound, while three strains were found which could utilize both. Of the remaining virulent strains, 27 utilized octopine and 14 utilized nopaline.

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The growth of crown-gall tumors on primary bean leaves (Phaseolus vulgaris L. cv. "Pinto") was promoted by the addition of d-lysopine, d-octopine, l-carnosine, or nopaline.

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An improved bioassay is described for a factor that promotes tumor growth which was first obtained from extracts of pinto bean leaves with crown gall tumors. Sixteen primary pinto bean leaves per sample are inoculated with sufficient Agrobacterium tumefaciens to initiate about 5 to 10 tumors per leaf and treated with tumor growth factor at day 3 after inoculation. The diameters of 30 to 48 round tumors (no more than 3 randomly selected per leaf) are measured per test sample at day 6.

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Mixtures of two strains of Agrobacterium from the species A. tumefaciens (11 strains), A. rhizogenes (6 strains), and A.

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Growth of tumors induced on primary leaves of bean plants by Agrobacterium tumefaciens was increased by the addition of lysopine and octopine. A detectable response was observed when as little as 1 microgram of these compounds was added per leaf, and the mean volume of the tumors was increased two- to threefold when greater amounts were applied. The specificity of the response and the unique association of these compounds with the tumors suggest that endogenous lysopine and octopine contribute to the growth characteristics of these tumors.

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The ability of 31 strains of Agrobacterium to initiate the production of a tumor growth factor (TGF) which is associated with crown-gall tumors on primary pinto bean leaves was determined. Extracts from bean leaves inoculated with these bacteria were tested and they showed that 16 of the 19 strains that induced tumors on the leaves also initiated TGF production. The three strains for which no TGF was detected were of low infectivity and included two strains of A.

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The number of tumors initiated by Agrobacterium tumefaciens strain B6 on primary pinto bean leaves was decreased when cells of an avirulent strain (IIBNV6) were included in the inoculum. With sufficient B6 cells to initiate ca. 50% of the maximal number of tumors per leaf, inhibition was detected at a 1:1 ratio of B6 to IIBNV6 cells and increased linearly with the logarithm of the number of IIBNV6.

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Lippincott, Barbara B. (Northwestern University, Evanston, Ill.), and James A.

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Treating cultures of Agrobacterium tumefaciens at 39 degrees to 48 degrees C reduces the infectivity of the bacteria without necessarily affecting viability. Destruction of the capacity to initiate tumor growth follows first-order kinetics from which rate constants for thermal inactivation are derived. From these rates, values for heat of activation of 56.

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