Developmental and Interprofessional Care of the Preterm Infant: Neonatal Intensive Care Unit Through High-Risk Infant Follow-up.

Practices in the neonatal intensive care unit (NICU) that reduce infant stress and respond to behavioral cues positively influence developmental outcomes. Proactive developmental surveillance and timely introduction of early intervention services improve outcomes for premature infants. A model that emphasizes infant development and a continuum of care beginning in the NICU with transition to outpatient monitoring and provision of early intervention services is hypothesized to support the most optimal outcomes for premature infants.

Protection from the nephrotoxicity of contrast dye.

Previous studies have reported a 4%-50% incidence of acute renal failure (ARF) following the use of radiocontrast media in patients with preexisting chronic renal insufficiency. In these studies, ARF was defined as a rise of the serum creatinine of at least 1 mg/dl above baseline. Using the same criteria, we studied 214 patients undergoing various intravascular radiocontrast media procedures.

Foscarnet alters antidiuretic hormone-mediated transport.

Therapy with foscarnet is associated with acute renal failure. Prior studies have emphasized foscarnet's proximal tubular toxicity, but there have been isolated reports of foscarnet-induced nephrogenic diabetes insipidus. As a phosphate analog, foscarnet is a competitive inhibitor of NaPO4 cotransport.

Dialysis-related amyloidosis manifested as masses in the buttocks.

A 40-year-old man had enlarging painful gluteal masses that developed after 17 years of hemodialysis. Pathologic examination revealed extensive deposition of beta 2-microglobulin amyloid. A bladder biopsy done during evaluation for possible transplantation also showed amyloid deposits.

The use of fluconazole in the management of Candida peritonitis in patients on peritoneal dialysis.

In patients receiving peritoneal dialysis, fungal peritonitis is generally impossible to eradicate with previously available therapy in the absence of catheter removal. Corbella et al. described a patient with fungal peritonitis treated with fluconazole without catheter removal.

Comparative effect of metals on antidiuretic hormone induced transport in toad bladder: specificity of mercuric inhibition of water channels.

We previously reported that HgCl2 inhibits water and urea flux in tissues fixed with glutaraldehyde after antidiuretic hormone (ADH) stimulation and suggested that the ADH-induced water channel may share characteristics of the red blood cell and proximal tubule water transport pathway. To determine the specificity of mercury's action, we examined the effect of numerous other metals. In tissues fixed after ADH stimulation, water flow and urea and sucrose permeabilities are maintained from mucosal bath pH 2.

Volunteer participation in feeding residents: training and supervision in a long-term care facility.

The increasing number of residents in long-term care facilities who require full and partial assistance during meals has created a need for volunteer support to enhance the quality of life for residents. The correlation between dependence in eating and the existence of swallowing disorders and the risk of aspiration in persons with swallowing disorders suggests that training must be given to volunteers who feed residents. A formalized program for volunteer training and supervision was implemented at Coler Memorial Hospital, a long-term care facility.

Coagulation and fibrinolytic responses to exercise and cold exposure.

This study examined the effect of acute cold exposure on coagulation (PTT) and fibrinolysis (ELT), and the effect of cooling on subsequent exercise-induced coagulation and fibrinolytic responses. Ten male volunteers were tested at 5 degrees C and 28 degrees C on alternate days. Each subject began by sitting quietly for 60 min.

The role of inhibin in adult male rats: the effect of inhibin deficiency and androgen antagonism on serum and pituitary gonadotrophins.

We examined the ability of inhibin-F contained in porcine follicular fluid (pFF) to regulate serum gonadotrophins in male rats made deficient in endogenous inhibin and unable to respond to normal endogenous androgen levels. Efferent duct ligation (EDL) effected endogenous inhibin deficiency and the anti-androgen flutamide (F) (13.4 mg/dose, sc once per day) raised the set point for androgen control of the hypothalamus to a level intermediate between the intact and castrate serum gonadotrophin levels.

The contribution of gonadostatin (inhibin-F) to the control of gonadotropin secretion in a simulated estrous cycle in steroid-treated ovariectomized rats.

We have examined the contribution of gonadostatin to the control of gonadotropin secretion throughout the rat estrous cycle. The estrous cycle was simulated in rats ovariectomized on diestrus-1, designated day 1 (D-1) by use of low or high level estradiol and progesterone Silastic implants. The steroid implant regimen simulated the major changes of these hormones in the blood during the course of the estrous cycle.

The dissociation and separation of bovine adenohypophysial cells.

Bovine adenhypophysial tissue was dissociated by sequential enzymatic incubation in a continuous flow system. Dispersed cells separated into discrete fractions after centrifugation in isopycnic bovine serum albumin gradients. The dispersed and separated cells were prepared for microscopic identification and differential counts by centrifugal cytology.