Metal complex-based TADF: design, characterization, and lighting devices.

The development of novel, efficient and cost-effective emitters for solid-state lighting devices (SSLDs) is ubiquitous to meet the increasingly demanding needs of advanced lighting technologies. In this context, the emergence of thermally activated delayed fluorescence (TADF) materials has stunned the photonics community. In particular, inorganic TADF material-based compounds can be engineered by chemical modification of the coordinated ligands and the type of metal centre, allowing control of their ultimate photo-/electroluminescence properties, while providing a viable emitter platform for enhancing the efficiency of state-of-the-art organic light-emitting diodes (OLEDs) and light-emitting electrochemical cells (LECs).

[Patient and public involvement at the German Center for Mental Health: achievements and challenges].

Background: Patient and public involvement (PPI) describes the participation of patients and relatives, i.e., experts by experience (EE), in the research process.

[The German Center for Mental Health : Innovative translational research to promote prevention, targeted intervention and resilience].

Background: Due to the high disease burden, the early onset and often long-term trajectories mental disorders are among the most widespread diseases with growing significance. The German Center for Mental Health (DZPG) was established to enhance research conditions and expedite the translation of clinically relevant findings into practice.

Objective: The aim of the DZPG is to optimize mental healthcare in Germany, influence modifiable social causes and to develop best practice models of care for vulnerable groups.

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers.

Current treatments of degenerated intervertebral discs often provide only temporary relief or address specific causes, necessitating the exploration of alternative therapies. Cell-based regenerative approaches showed promise in many clinical trials, but limitations such as cell death during injection and a harsh disk environment hinder their effectiveness. Injectable microscaffolds offer a solution by providing a supportive microenvironment for cell delivery and enhancing bioactivity.

The use of a Mamdani-type fuzzy model for assessing the performance of a boom stabilization systems in a field sprayer.

Fuzzy logic models are increasingly used to control simple and complex devices, as well as entire operating systems. In this study, a fuzzy logic model was applied to assess the performance a boom stabilization system in a field sprayer. The model was tested on a field sprayer with a trapezoid system for stabilizing the sprayer boom with a length of 21 m.

Impact of antibiotic perturbation on fecal viral communities in mice.

Viruses and bacteriophages have a strong impact on intestinal barrier function and the composition and functional properties of commensal bacterial communities. Shifts of the fecal virome might be involved in human diseases, including inflammatory bowel disease (IBD). Loss-of-function variants in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene are associated with an increased risk of developing Crohn's disease, a subtype of human chronic IBD, where specific changes in fecal viral communities have also been described.

Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML).

Acute myeloid leukemia (AML) is characterized by complex molecular alterations and driver mutations. Elderly patients show increased frequencies of IDH mutations with high chemoresistance and relapse rates despite recent therapeutic advances. Besides being associated with global promoter hypermethylation, IDH1 mutation facilitated changes in 3D DNA-conformation by CTCF-anchor methylation and upregulated oncogene expression in glioma, correlating with poor prognosis.

Impact of electron-phonon coupling on electron transport through T-shaped arrangements of quantum dots in the Kondo regime.

We calculate the conductance through strongly correlated T-shaped molecular or quantum dot systems under the influence of phonons. The system is modelled by the extended Anderson-Holstein Hamiltonian. The finite-U mean-field slave boson approach is used to study many-body effects.

A blind spot in mental healthcare? Psychotherapists lack education and expertise for the support of adults on the autism spectrum.

Most autistic adults experience mental health problems. There is a great demand for psychotherapeutic support that addresses the specific needs of autistic individuals. However, people with autism encounter difficulties trying to access diagnostic and therapeutic services.

Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor-Immune Interactions.

Extracellular vesicles (EVs) serve as trafficking vehicles and intercellular communication tools. Their cargo molecules directly reflect characteristics of their parental cell. This includes information on cell identity and specific cellular conditions, ranging from normal to pathological states.

Kondo effects in small-bandgap carbon nanotube quantum dots.

We study the magnetoconductance of small-bandgap carbon nanotube quantum dots in the presence of spin-orbit coupling in the strong-correlations regime. A finite-U slave-boson mean-field approach is used to study many-body effects. Different degeneracies are restored in a magnetic field and Kondo effects of different symmetries arise, including SU(3) effects of different types.

Identification of the polyketide synthase PKS7 responsible for the production of lecanoric acid and ethyl lecanorate in Claviceps purpurea.

Claviceps purpurea is a plant pathogenic fungus which is still highly relevant in modern agriculture as it infects grasses such as rye and wheat. The disease caused by the consumption of contaminated grain or flour has been known since the Middle Ages and is termed ergotism. The main cause for the toxicity of this fungus is attributed to the ergot alkaloids.

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.

Background & Aims: Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER stress. We studied the pathways that regulate ATF6 and its role for inflammation in IECs.

NOD2 Influences Trajectories of Intestinal Microbiota Recovery After Antibiotic Perturbation.

Background & Aims: Loss-of-function variants in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) impair the recognition of the bacterial cell wall component muramyl-dipeptide and are associated with an increased risk for developing Crohn's disease. Likewise, exposure to antibiotics increases the individual risk for developing inflammatory bowel disease. Here, we studied the long-term impact of NOD2 on the ability of the gut bacterial and fungal microbiota to recover after antibiotic treatment.

Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles.

Inflammasomes are cytosolic protein complexes, which orchestrate the maturation of active IL-1β by proteolytic cleavage via caspase-1. Although many principles of inflammasome activation have been described, mechanisms that limit inflammasome-dependent immune responses remain poorly defined. Here, we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1β generation by interfering with caspase-1 activity.

Relationship Between Hereditary Cancer Syndromes and Oncotype DX Recurrence Score.

Background: Oncotype DX (ODX) is a genomic assay of tumor tissue that is utilized to predict the likelihood of recurrence and benefit of chemotherapy in breast cancer patients. Five to 10% of breast cancers are hereditary, and hereditary syndromes may not be uncovered through family history alone. We hypothesized that high ODX recurrence score (RS) may signal a potential hereditary cancer risk.

The Tribaloy T-800 Coatings Deposited by Laser Engineered Net Shaping (LENS).

A Tribaloy family of alloys (CoMoCrSi) are characterized by a substantial resistance to wear and corrosion within a wide range of temperatures. These properties are a direct result of their microstructure including the presence of Laves phase in varying proportions. Tribaloy T-800 exhibits the highest content of Laves phase of all other commercial Tribaloy alloys, which provides high hardness and wear resistance.

Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2.

Whole-genome and whole-exome sequencing of individual patients allow the study of rare and potentially causative genetic variation. In this study, we sequenced DNA of a trio comprising a boy with very-early-onset inflammatory bowel disease (veoIBD) and his unaffected parents. We identified a rare, X-linked missense variant in the NAPDH oxidase gene (c.

Evaluation of regenerative processes in the pig model of intervertebral disc degeneration after transplantation of bone marrow-derived mesenchymal stem cells.

Introduction: The pathophysiology of degenerative disc disease (DDD) is complex and not fully understood. While surgical treatment and appropriate rehabilitation offer relief of acute symptoms, there is a need to find tissue engineering strategies for intervertebral disc repair to restore healthy higher and histological structure. The purpose of this study was to estimate the survival rate of transplanted cells and their post-delivery integration level at the damage site.

Outpatient Psychotherapy for Adults with High-Functioning Autism Spectrum Condition: Utilization, Treatment Satisfaction, and Preferred Modifications.

Many adults with autism spectrum condition (ASC) desire outpatient psychotherapy (PT). This study compared reasons for seeking PT, experiences with PT, and modifications preferred with respect to PT of individuals with ASC to non-autistic individuals with depression (MDD). Furthermore, factors predictive for treatment satisfaction were identified in individuals with ASC.