Publications by authors named "Liping Sun"

Asthma is a prevalent chronic pediatric lung disease which is commonly perceived as a syndrome of airway inflammation characterized by cough and wheeze in clinic. Klotho is implicated in diverse cellular activities, including inflammation, oxidative stress and apoptosis. This paper aims to explore the role of klotho in asthma and investigate the relevant molecular reaction mechanisms.

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Astaxanthin, a lipid-soluble carotenoid, is widely recognized for its health-promoting properties. However, its use in functional foods is limited due to its low water solubility, chemical instability, and poor bioavailability. This study evaluated the potential of esterified starch-stabilized emulsions as astaxanthin carriers.

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Background: Bacterial pneumonia is most prevalent among all pneumonia types, with Streptococcus pneumoniae being the main pathogen. Qingfei Yin (QFY) is a traditional Chinese medicine formula used in the clinical treatment of bacterial pneumonia. Previous studies have confirmed the multi-target and -effect characteristics of QFY in treating S.

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Purpose: This study aims to compare the effectiveness of ultrasound-guided intra-articular (IA) injections with medial branch nerve blocks in treating lumbar facet joint pain.

Methods: This retrospective study enrolled 94 patients clinically diagnosed with lumbar facet joint pain. Diagnostic blocks confirmed the diagnosis in 82 patients, evidenced by a pain visual analog score (VAS) reduction of at least 50% immediately following the injection.

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Background: Maternal fear of childbirth fluctuates throughout pregnancy. However, no studies have investigated the changing characteristics and influencing factors of fear of childbirth.

Aims: This study aimed to identify the trajectory patterns of fear of childbirth in third-trimester primiparas and to examine the factors influencing these patterns.

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Background: Kawasaki disease (KD) is an acute pediatric vasculitis that can lead to coronary artery aneurysms and severe cardiovascular complications, often presenting with obvious fever in the early stages. In current clinical practice, distinguishing KD from other febrile illnesses remains a significant challenge. In recent years, some researchers have explored the potential of machine learning (ML) methods for the differential diagnosis of KD versus other febrile illnesses, as well as for predicting coronary artery lesions (CALs) in people with KD.

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Electronic effects of organic functional groups play a fundamental role in determining the rate and/or direction of organic chemical reactions. The implementation of this concept in selective organic catalysis is achieved by tuning the electronic effects of organic functional groups to alter the corresponding reactivity. However, this approach has hardly been applied to modulate the band structure of inorganic materials.

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Objectives: This study aimed to analyze the safety, efficacy, and application prospects of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperthyroidism.

Methods: Eight patients with primary hyperthyroidism who underwent ultrasound-guided glandular volume reduction between January 2021 and December 2022 were included in this study. Pre- and postablative examinations, including grayscale ultrasound, contrast-enhanced ultrasound (CEUS), laboratory examination, antithyroid drug (ATD) dosage, and quality of life (QoL) assessment via Thyroid-Specific Patient-Reported Outcome Short-Form (ThyPRO-39), were analyzed retrospectively.

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Key Clinical Message: We report three cases of IMN from our center, where patients received a single dose of telitacicept after showing no response to conventional treatments. Although one case did not respond, the other two cases achieved complete or partial remission of proteinuria. These cases illustrates the telitacicept may offer new hope for the treatment of IMN.

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Article Synopsis
  • Informed variance estimates are critical for determining sample size in clinical trials, particularly for adult Type 2 diabetes studies.
  • An analysis of 14,106 subjects from FDA submissions revealed that accurate variance estimates can help streamline sample requirements for future trials.
  • The research indicates that smaller sample sizes may not compromise the validity of results, potentially speeding up recruitment and study outcomes in future endocrinology research.
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Preclinical studies demonstrating high cure rates with PD1/PD-L1 combinations have led to numerous clinical trials, but emerging results are disappointing. These combined immunotherapies are commonly employed for patients with refractory tumors following prior treatment with cytotoxic agents. Here, we uncovered that the post-chemotherapy tumor presents a unique mechanical microenvironment characterized by an altered extracellular matrix (ECM) elasticity and increased stiffness, which facilitate the development of aggressive tumor phenotypes and confer resistance to checkpoint blocking therapy.

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Background: Arecanut seed is an important traditional medicine in Southeast Asia. It has been presented in a clinical formula to treat osteoporosis (OP) in China. Arecanut seed is abundant in phenols.

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Article Synopsis
  • A study aimed to create a reliable model using conventional and contrast-enhanced ultrasound features to predict microinvasion in breast ductal carcinoma in situ (DCIS) before surgery.
  • Researchers analyzed data from 163 patients with DCIS, applying logistic regression to identify key risk factors and assess the model's performance using different validation sets.
  • The final predictive model, represented as a nomogram, demonstrated strong accuracy and clinical usefulness, outperforming individual ultrasound methods in forecasting microinvasion risk.
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Scope: Type 2 diabetes mellitus (T2DM) is a metabolic disease with a major global public health effect. Rambutan peel polyphenols (RPPs) have been reported to exert hypoglycemic activity. However, few studies have been explored from the viewpoint of gut microbiota and its metabolites.

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  • This study evaluated how well targeted biopsy (TB) and unilateral systematic biopsy (SB) can detect clinically significant prostate cancer (csPCa) in men with MRI-detected lesions classified as PI-RADS ≥ 3.
  • The research involved 222 patients and compared the effectiveness of TB combined with ipsilateral SB, TB with contralateral SB, and TB alone in diagnosing csPCa.
  • Results indicated that TB + ipsilateral SB had the highest sensitivity and was a more effective method for detecting csPCa while also minimizing the number of biopsies needed compared to traditional SB methods.
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  • Forsythoside B is being studied for its potential to treat Streptococcus pneumoniae infections by inhibiting pneumolysin, which is a toxin that can harm cells.
  • Experiments demonstrated that Forsythoside B successfully inhibited the activity of pneumolysin, protected lung cells from damage, and did not interfere with the growth of the bacteria.
  • In mouse models, it improved survival rates and reduced lung inflammation, highlighting its promise as a treatment for pneumococcal pneumonia.
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  • Xiao-er-kang-du (XEKD) capsules are a Chinese herbal remedy effectively treating upper respiratory infections in kids, specifically targeting symptoms like fever and cough, though its exact mechanism against the influenza B virus (IBV) remains unclear.
  • This study aims to investigate how XEKD works against the IBV and determine its curative effects through various experimental methods, including chemical analysis and cellular studies.
  • Results indicate that XEKD fights IBV by enhancing autophagy via the mTOR/ULK1/Beclin1/VPS34 pathway, reducing lung tissue damage and suggesting potential for XEKD as a future treatment for IBV infections.
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Article Synopsis
  • - The multi-attention guided UNet (MAUNet) is proposed for improved segmentation of thyroid nodules, addressing challenges due to their varying sizes and positions using a multi-scale cross attention (MSCA) module for better feature extraction.
  • - A dual attention (DA) module enhances information sharing between the encoder and decoder in the UNet architecture, further refining segmentation results.
  • - Extensive tests on ultrasound images from 17 hospitals reveal that MAUNet achieves high Dice scores (around 0.9) and outperforms existing segmentation methods, demonstrating effective generalization across diverse datasets while maintaining patient privacy through federal learning.
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Objective: To detect the differentially expressed regulatory miRNAs in the late stage of red blood cell (RBC) preservation and predict their roles.

Methods: Suspended RBCs with different storage periods of 35 day, 42 day, and 50 day were collected for routine blood tests, RNA extraction, and preparation of small RNA sequencing libraries. The constructed libraries were sequenced and the biological functions of differential miRNAs in RBCs in the late storage were analyzed by bioinformatics.

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Introduction: Bunge, belonging to the Acer genus in the Aceraceae family, is a commonly planted afforestation species across China, Japan, Korea, Europe, and North America. Renowned for its vibrant fall colors, it holds significant ecological and ornamental value.

Methods: In this study, ' Lihong ' was used as the research object.

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High hydrostatic pressure (HHP) treatment was combined with octenyl succinic anhydride (OSA) modification of quinoa starch (QS) to improve esterification efficiency. The modified QS was used as a stabilizer to prepare a Pickering emulsion. The results showed that the HHP treatment disrupted the morphology and crystalline structure of QS, exposed numerous hydrophilic hydroxyl groups, and added esterification reaction sites.

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Background: Per- and polyfluoroalkyl substance (PFAS) exposure and cardiovascular disease are controversial. We aimed to assess the association between serum PFAS exposure and cardiovascular health (CVH) in U.S.

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Ultrasound image super-resolution (SR) aims to transform low-resolution images into high-resolution ones, thereby restoring intricate details crucial for improved diagnostic accuracy. However, prevailing methods relying solely on image modality guidance and pixel-wise loss functions struggle to capture the distinct characteristics of medical images, such as unique texture patterns and specific colors harboring critical diagnostic information. To overcome these challenges, this paper introduces the Multi-Modal Regularized Coarse-to-fine Transformer (M2Trans) for Ultrasound Image SR.

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Background: With the increasing use of hormone replacement therapy (HRT), there is a need to understand its impact on the occurrence of female malignant tumors. This systematic review and meta-analysis aimed to assess the risk of ovarian cancer associated with HRT and its related risk factors.

Methods: PUBMED, OVID, Embase, Cochrane, and Web of Science were searched from 1980 to April 2022 to identify studies on the risk of ovarian cancer and hormone replacement therapy.

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