Publications by authors named "Liping Mao"

Background: Oat (Avena sativa L.) is a valuable crop due to its strong adaptability to marginal environments, making it an important component of agricultural systems in regions where other cereals may not thrive. The application of chemical fertilizer can influence oat hay and grain yield significantly.

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Gallibacterium anatis (G. anatis) is an opportunistic pathogen previously associated with deaths in poultry and is also a pathogen that rarely causes human diseases. G.

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  • The study investigates the link between protein quantitative trait loci (pQTL-SNPs) and lung adenocarcinoma (LUAD) risk by analyzing plasma from female LUAD patients and healthy controls, along with tumor tissues.
  • It identifies 7 significant pQTL-SNPs related to altered LUAD risk, showing decreased levels of certain proteins which may act as tumor suppressors in patients' plasma and tumor tissues.
  • The findings suggest that mutations in 4 specific pQTL-SNPs can affect the expression of target proteins (BST1, NRP1, and APOH), influencing the risk of developing LUAD either by promoting or inhibiting tumorigenesis.
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Background: Intrahepatic cholangiocarcinoma (iCCA) is one of the most lethal malignancies and highly heterogeneous. We thus aimed to identify and characterize iCCA cell subpopulations with severe malignant features.

Methods: Transcriptomic datasets from three independent iCCA cohorts (iCCA cohorts 1-3, n = 382) and formalin-fixed and paraffin-embedded tissues from iCCA cohort 4 (n = 31) were used.

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The optimal treatment endpoints and duration of continuous therapy for multicentric Castleman disease (MCD) remain controversial. We retrospectively analyzed data from 123 patients with Human Herpesvirus (HHV)-8 negative MCD. We demonstrated that continuous therapy significantly enhanced progression-free survival (PFS) in patients who achieved an optimal response after initial treatment.

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Rapid evolution of (PRRSV) is the bottleneck for effective prevention and control of PRRS. Thus, understanding the prevalence and genetic background of PRRSV strains in swine-producing regions is important for disease prevention and control. However, there is only limited information about the epizootiological situation of PRRS in the Xinjiang Uygur Autonomous Region, China.

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  • The study aimed to identify new plasma protein biomarkers for lung adenocarcinoma (LUAD) through proteomics analysis and validation in LUAD patients and healthy controls.
  • GPI and PGD were found to be upregulated in LUAD patients' plasma, with a significant correlation between their plasma and tissue levels, as well as a negative correlation to tumor blood vessel normalization.
  • Findings suggest GPI and PGD could serve as potential diagnostic and prognostic biomarkers, helping to assess the risk of metastasis and tumor severity in LUAD patients.
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  • The study examines the effectiveness and safety of the VAA regimen (Venetoclax, Cytarabine, and Azacitidine) for patients with relapsed/refractory acute myeloid leukemia (AML).
  • Out of 30 enrolled patients, 63.3% achieved a composite complete remission, with many showing no detectable disease.
  • The treatment was generally safe, with common side effects including neutropenia and infections, but no treatment-related deaths occurred.
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Resistance to chemotherapy remains a formidable obstacle in acute myeloid leukemia (AML) therapeutic management, necessitating the exploration of optimal strategies to maximize therapeutic benefits. Venetoclax with 3+7 daunorubicin and cytarabine (DAV regimen) in young adult de novo AML patients is evaluated. 90% of treated patients achieved complete remission, underscoring the potential of this regimen as a compelling therapeutic intervention.

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  • This study investigated the consistency of mRNAs and proteins in lung adenocarcinoma (LUAD) across different populations while creating a prognostic model for better survival prediction.
  • Researchers standardized various data types to find common differentially expressed mRNAs and proteins, noting that ethnic diversity affects consistency rates significantly.
  • The resulting survival model, based on eight identified hub mRNAs and clinical factors, shows promise for predicting LUAD outcomes across diverse groups and highlights the importance of integrating genetic diversity in cancer research.
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Gilteritinib, a potent FMS-like tyrosine kinase 3 (FLT3) inhibitor, was approved for relapsed/refractory (R/R) FLT3-mutated acute myeloid leukaemia (AML) patients but still showed limited efficacy. Here, we retrospectively analysed the efficacy and safety of different gilteritinib-based combination therapies (gilteritinib plus hypomethylating agent and venetoclax, G + HMA + VEN; gilteritinib plus HMA, G + HMA; gilteritinib plus venetoclax, G + VEN) in 33 R/R FLT3-mutated AML patients. The composite complete response (CRc) and modified CRc (mCRc) rates were 66.

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  • Scientists are studying how a process called alternative polyadenylation (APA) affects the development of lung cancer (LUAD) and how it might help doctors predict patient outcomes.
  • They found important genes connected to APA that could help tell how well patients might do, and tested these in groups from Asia and the USA.
  • The research created a special tool to help predict outcomes for patients in Asia, showing it could be useful for personalizing treatment and diagnosing lung cancer better.
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endophthalmitis is a devastating eye infection that causes rapid blindness through the release of extracellular tissue-destructive exotoxins. The phagocytic and antibacterial functions of ocular cells are the keys to limiting ocular bacterial infections. In a previous study, we identified a new virulence gene, (different from the original gene), that was strongly associated with the gene of .

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Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common subtypes of lymphoma. Clinical biomarkers are still required for DLBCL patients to identify high-risk patients. Therefore, we developed and validated the platelet-to-albumin (PTA) ratio as a predictor for DLBCL patients.

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As reported, SETD2 is recurrently mutated in acute myeloid leukaemia (AML), but knowledge about the specifics is limited. We enrolled 530 consecutive newly diagnosed AML patients in our study, and we analysed the distribution pattern and prognostic role of SETD2 mutation in AML. SETD2 mutation was found to affect 6.

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Genetic heterogeneity poses a great challenge to the understanding and management of acute myeloid leukemia (AML). Knowledge of the IKZF1 mutation in AML specifically is extremely limited. In a previous work, we described the distribution pattern of IKZF1 mutation in AML, but its clinical impact has remained undefined due to the limited number of cases.

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