Self-Powered Photoelectrochemistry Biosensor for Ascorbic Acid Determination in Beverage Samples Based on Perylene Material.

Ascorbic acid plays an important role in the synthesis and metabolism of the human body. However, it cannot be synthesized by the human body and needs to be supplemented from exogenous food intake. Ascorbic acid is easily degraded during storage and heating, often causing its content in food to change.

Enhancing the phytoextraction capacity of chromium-contaminated soil by co-addition of garbage enzymes and microelectrolytic iron-carbon fillers.

Most improved strategies for phytoextraction do not achieve a synergistic enhancement of chromium (Cr) accumulation capacity and biomass. This study investigated the impacts of co-addition of garbage enzyme (GE) and microelectrolytic iron-carbon filler (MF) on soil physicochemical properties, as well as form and uptake of Cr during aging and phytoextraction process. The response of rhizosphere microbial community to co-addition and its role in enhancing the remediation performance of ryegrass was further analyzed.

Dual-mode electrochemical and electrochemiluminescence detection of dopamine based on perylene diimide self-assembly material.

The self-assembly material N,N-bis-(3-dimethyl aminopropyl)-3,4,9,10-perylene tetracarboxylic acid diimide (PDI) is reported to show electrochemical (EC)/electrochemiluminescence (ECL) property for designing new dual-mode dopamine (DA) sensors. KSO significantly improved the EC reduction current at -0.346 V and ECL intensity at -0.

Etomidate Inhibits Hepatic Ischemia-Reperfusion Injury Depending on the Activation of Nrf2-HO-1 Signaling Pathway.

Hepatic ischemia-reperfusion (I/R) injury (HIRI) is recognized as a local aseptic inflammatory response driven by innate immunity and is considered a leading cause of early organ dysfunction and failure following liver transplantation. Etomidate (Eto), an anesthetic drug known for its ability to inhibit inflammatory response and apoptosis, was the focus of our investigation. In this study, we conducted hepatic I/R surgery on C57 mice, analyzing liver damage through histopathology.

Enhanced-electrochemiluminescence biosensor for detecting miRNA-21 based on a CuO-mediated click reaction and catalytic hairpin self-assembly.

MicroRNAs (miRNAs) are closely associated with cancer and have been considered cancer biomarkers. Herein, we propose an electrochemiluminescence (ECL) biosensor for detecting miRNA-21 based on target-induced catalytic hairpin self-assembly (CHA) and CuO-mediated azide-alkyne cycloaddition. Two hairpin DNAs were employed: one was immobilized on magnetic beads (HP2) and another was labeled with CuO (HP1-CuO).

Diverse Head-to-Tail Sequences in the Circular Genome of Human Bocavirus Genotype 1 among Children with Acute Respiratory Infections Implied the Switch of Template Chain in the Rolling-Circle Replication Model.

Head-to-tail sequences have been reported in human bocavirus (HBoV) 1-4. To reveal their features and functions, HBoV DNA was screened among respiratory specimens from pediatric patients with an acute respiratory infection (ARI) between April 2020 and December 2022, followed by HBoV genotyping. Head-to-tail sequences were detected using nested PCR, TA cloning, and Sanger sequencing, and these findings were confirmed by mNGS and amplicon sequencing.

Recombinant collagen for the repair of skin wounds and photo-aging damage.

The skin, being the body's primary defense mechanism, is susceptible to various injuries such as epidermal wounds, natural aging, and ultraviolet-induced damage. As a result, there is growing interest in researching skin repair methods. Traditional animal-derived collagen, widely available on the market, poses risks due to its immunogenicity and potential for viral contamination.

Identification of angiogenesis-related subtypes and risk models for predicting the prognosis of gastric cancer patients.

Gastric cancer (GC) is a leading cause of cancer-related mortality and is characterized by significant heterogeneity, highlighting the need for further studies aimed at personalized treatment strategies. Tumor angiogenesis is critical for tumor development and metastasis, yet its role in molecular subtyping and prognosis prediction remains underexplored. This study aims to identify angiogenesis-related subtypes and develop a prognostic model for GC patients.

The Effect of Attentional Bias on Emotions in Patients with Breast Cancer.

Background: Attentional bias may influence the emotional experiences of breast cancer patients, both positively and negatively. This study aimed to investigate attentional bias in breast cancer patients and its impact on their emotions.

Method: Thirty-eight breast cancer patients completed a modified dot-probe task and the Depression Anxiety and Stress Scale to assess attentional bias and emotional states.

The relationship between psychological distress and cognitive failure among breast cancer survivors: a network analysis.

Background: Psychological distress is highly prevalent and has a severe impact on the quality of life among breast cancer survivors. This type of distress is associated with cognitive failure. However, previous studies have focused solely on the total scale scores of these two concepts while ignoring the unique relationship between specific components.

Nutrient removal efficacy and microbial dynamics in constructed wetlands using Fe(III)-mineral substrates for low carbon-nitrogen ratio sewage treatment.

This study evaluated the roles of two common sources of Fe(III)-minerals-volcanic rock (VR) and synthetic banded iron formations from waste iron tailings (BIF-W)-in vertical flow-constructed wetlands (VFCWs). The evaluation was conducted in the absence of critical environmental factors, including Fe(II), Fe(III), and soil organic matter (SOM), using metagenomic analysis and integrated correlation networks to predict nitrogen removal pathways. Our findings revealed that Fe(III)-minerals enhanced metabolic activities and cellular processes related to carbohydrate decomposition, thereby increasing the average COD removal rates by 10.

Photoelectrochemical analysis of Pb based on Au@PTCA Schottky junction with Pb-G quadruplex structure.

Herein, a novel photoelectrochemical (PEC) aptasensor using gold nanoparticles@3,4,9,10-perylene tetracarboxylic (Au@PTCA) Schottky junction as the effective optoelectronic material and lead ion (Pb)-G quadruplex structure as the efficient quencher was constructed for the detection of Pb with high sensitivity and excellent selectivity. Au@PTCA Schottky junction, which was proposed by the reduction of Au NPs on the PTCA surface, exhibited a strong unidirectional conductivity, which could generate a significantly enhanced PEC signal compared with the pure PTCA. The Pb-G quadruplex structure with a large spatial hindrance effect was formed when the target Pb was present owing to the occurrence of the specific recognition between Pb and its aptamer S1.

A novel dual-signal output strategy for POCT of CEA based on a smartphone electrochemical aptasensing platform.

A smartphone-based electrochemical aptasensing platform was developed for the point-of-care testing (POCT) of carcinoembryonic antigen (CEA) based on the ferrocene (Fc) and PdPt@PCN-224 dual-signal labeled strategy. The prepared PdPt@PCN-224 nanocomposite showed a strong catalytic property for the reduction of HO. Phosphate group-labeled aptamer could capture PdPt@PCN-224 by Zr-O-P bonds to form PdPt@PCN-224-P-Apt.

The impact of telecom industry employees' stress perception on job burnout: moderated mediation model.

Background: The rapid development of the telecommunications industry in the post-COVID-19 era has brought tremendous pressure to employees making them a high-risk group for job burnout. However, prior research paid less attention to the burnout of employees. Furthermore, social support and gender have separate effects on job burnout.

Distinguishable Magnetic Reporter Coordination with Buoyancy-Magnetism Separation for Immobilization-Free Dual-Target Electrochemical Immunosensing.

Simultaneous sensitive and precise determination of multibiomarkers is of great significance for improving detection efficiency, reducing diagnosis and treatment expenses, and elevating survival rates. However, the development of simple and portable biosensors for simultaneous determination of multiplexed targets in biological fluids still faces challenges. Herein, a unique and versatile immobilization-free dual-target electrochemical biosensing platform, which combines distinguishable magnetic signal reporters with buoyancy-magnetism separation, was designed and constructed for simultaneous detection of carcinoembryonic (CEA) and α-fetoprotein (AFP) in intricate biological fluids.

Dual-potential ratiometric electrochemiluminescence based on single emitter and single coreactant for the sensitive detection of carcinoembryonic antigen.

Dual-potential ratiometric electrochemiluminescence (ECL) is in favor of resistance to environmental interference. However, two kinds of emitters or coreactants, and a wide scan potential range (>2 V) are mandatory. This work developed a new dual-potential ratiometric ECL sensor for detection of carcinoembryonic antigen (CEA) using single emitter (luminol) and single coreactant (HO) with a mild potential range from -0.

Different biological responses of Skeletonema costatum and Prorocentrum donghaiense to polymetallic nodules from seawaters.

The negative impacts of polymetallic nodules mining on deep-sea benthic organisms have been widely established, but there is still a lack of understanding of the environmental impact on the surface ocean scenario. Phytoplankton growth experiment was conducted to determine the biological effect of polymetallic nodules on Prorocentrum donghaiense and Skeletonema costatum. The results showed that regardless of concentration and particle size, polymetallic nodules show a promoting effect on P.

A perylene diimide electrochemical probe with persulfate as a signal enhancer for dopamine sensing.

Dopamine (DA) is an important biomarker related to parkinsonism, schizophrenia and renal disease. Traditional electrochemical sensors for DA were based on the direct electrochemical oxidation of DA. In this paper, we report a new sensing strategy using ,'-di(trimethylaminoethyl)perylene diimide (TMPDI) as an electrochemical probe and KSO as a signal enhancer for DA detection between 0 and -0.

A smartphone-based electrochemical POCT for CEA based on signal amplification of ZrMOFs.

Carcinoembryonic antigen (CEA) is a biomarker of high expression in cancer cells. Highly sensitive and selective detection of CEA holds significant clinical value in the diagnosis, monitoring and efficacy evaluation of malignant tumors. In this work, a smartphone-based electrochemical point-of-care testing (POCT) platform for the detection of CEA was developed based on a ZrMOF signal amplification strategy.

BIRC5 facilitates cisplatin-chemoresistance in a mA-dependent manner in ovarian cancer.

Cisplatin-based chemotherapy is the standard treatment for metastatic ovarian cancer (OC). However, chemoresistance continues to pose significant clinical challenges. Recent research has highlighted the baculoviral inhibitor of the apoptosis protein repeat-containing 5 (BIRC5) as a member of the inhibitor of the apoptosis protein (IAP) family.

Tungsten-based polyoxometalate nanoclusters with remarkable reactive oxygen species-scavenging activity efficiently quenched luminol-based electrochemiluminescence for sensitive detection of Her-2.

This study aimed to develop a quenching-type electrochemiluminescence (ECL) immunosensor for human epidermal growth factor receptor (Her-2) detection. Firstly, Pd/NiFeOx nanoflowers decorated by in situ formation of gold nanoparticles (Au NPs) and 2D TiC MXene nanosheets were synthesized (AuPd/NiFeOx/TiC) as carriers to load luminol and primary antibodies. Impressively, AuPd/NiFeOx/TiC with excellent peroxidase-like activity could accelerate the decomposition of the coreactant HO generating more reactive oxygen species (ROSs) under the working potential from 0 to 0.

An electrochemical ratiometric biosensor for the detection of dopamine based on an MXene-Au nanocomposite.

Compared with single signal detection, a ratiometric biosensor could offer more accurate and reliable results. Here, a ratiometric electrochemical biosensor for the sensitive and accurate detection of dopamine was developed based on the strong adsorption ability of MXene-Au toward methylene blue, an inner reference element. This ratiometric sensing strategy opened up a new avenue for the development of a ratiometric platform.