Publications by authors named "Lioudmila A Lebedeva"
Article Synopsis
- The study reveals that orphan nuclear receptors, specifically SF-1 and liver receptor homolog 1, are regulated by SUMO modification, which suppresses their activity.
- Mutating certain lysine residues or introducing SUMO isopeptidase SENP1 significantly boosts the activity of these receptors, suggesting that SUMO modification is crucial in regulating their function.
- The findings indicate that direct interaction between sumoylated SF-1 and the DEAD-box protein DP103 plays a key role in this repression, involving specific E3-SUMO ligase candidates that enhance this SUMOylation process.
