Publications by authors named "Lionel Pretat"
Article Synopsis
- The study investigates how IL-16, a cytokine, affects the replication of Tropheryma whipplei in human macrophages by disrupting the endocytic pathway.
- IL-16 enhances the bacteria's ability to replicate while inhibiting the formation of phagolysosomes, which are essential for bacterial elimination.
- The findings reveal that blocking IL-16 can reduce T. whipplei replication and improve phagolysosome formation, highlighting a new role for IL-16 in modulating immune response during infection.
Coxiella burnetii, the agent of Q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category B. C. burnetii survives within myeloid cells by subverting receptor-mediated phagocytosis and preventing phagosome maturation.
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