Cardiopulmonary Exercise Testing Provides Additional Prognostic Information in Cystic Fibrosis.

Rationale: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in cystic fibrosis (CF) in the context of current clinical management, when controlling for other known prognostic factors, is unclear.

Objectives: To determine the prognostic value of CPET-derived measures beyond peak oxygen uptake ( opeak) following rigorous adjustment for other predictors.

Methods: Data from 10 CF centers in Australia, Europe, and North America were collected retrospectively.