Publications by authors named "Linzi H Shann"
Growth factor combination for chondrogenic induction from human mesenchymal stem cell.
Biochem Biophys Res Commun
July 2004
Article Synopsis
- Over the past decade, new strategies for cartilage engineering have emerged, with stem cell induction being a promising method using mesenchymal stem cells (MSCs) due to their pluripotency and availability.
- The research demonstrated that by cycling growth factors like TGF-beta3, BMP-6, and IGF-1, human bone marrow MSCs (hBMSCs) can be effectively induced to differentiate into chondrocytes, exhibiting characteristics such as morphology and extracellular matrix formation.
- The study concluded that specific combinations of growth factors, particularly TGF-beta3 with BMP-6 or IGF-1, significantly enhance chondrogenesis, making these combinations crucial for cartilage tissue engineering in vitro.