Publications by authors named "Linzi Chen"
Article Synopsis
- The study reviews literature from 2013 to 2023, revealing a growing interest in the link between mitochondrial function and colorectal cancer (CRC), with annual publications increasing.
- China leads in research output, but the US has a higher citation rate per publication, indicating a disparity in research impact.
- Key focus areas include the CRC tumor microenvironment and mitochondria-targeted therapies, with a call for collaboration to enhance treatment strategies and validate mitochondrial pathways as potential drug targets.
Background: Drug resistance is the primary obstacle to advanced tumor therapy and the key risk factor for tumor recurrence and death. 5-Fluorouracil (5-FU) chemotherapy is the most common chemotherapy for individuals with colorectal cancer, despite numerous options.
Methods: The Gene Expression Omnibus database was utilized to extract expression profile data of HCT-8 human colorectal cancer wild-type cells and their 5-FU-induced drug resistance cell line.
Background: Traditional Chinese medicine, JianpiJiedu decoction (JPJDF), has been utilized in colorectal cancer (CRC) treatment for over forty years. The potential of JPJDF to inhibit CRC through modulation of intestinal microbiota and their metabolites remains uncertain.
Aims: This study aims to further investigate the therapeutic mechanisms of JPJDF in CRC.