A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes.

Background: The large inter-individual variability in immune-cell composition and function determines immune responses in general and susceptibility o immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown.

Methods: Blood samples were collected from 243 patients with T1D of Dutch descent.