Bounding the Softwired Parsimony Score of a Phylogenetic Network.

In comparison to phylogenetic trees, phylogenetic networks are more suitable to represent complex evolutionary histories of species whose past includes reticulation such as hybridisation or lateral gene transfer. However, the reconstruction of phylogenetic networks remains challenging and computationally expensive due to their intricate structural properties. For example, the small parsimony problem that is solvable in polynomial time for phylogenetic trees, becomes NP-hard on phylogenetic networks under softwired and parental parsimony, even for a single binary character and structurally constrained networks.

Exploring spaces of semi-directed level-1 networks.

Semi-directed phylogenetic networks have recently emerged as a class of phylogenetic networks sitting between rooted (directed) and unrooted (undirected) phylogenetic networks as they contain both directed as well as undirected edges. While various spaces of rooted phylogenetic networks and unrooted phylogenetic networks have been analyzed in recent years and several rearrangement moves to traverse these spaces have been introduced, little is known about spaces of semi-directed phylogenetic networks. Here, we propose a simple rearrangement move for semi-directed phylogenetic networks, called cut edge transfer (CET), and show that the space of semi-directed level-1 networks with precisely k reticulations is connected under CET.

Barriers and Facilitators to Breast Cancer Screening for Women With Severe Mental Illness.

Background: Women with severe mental illness (SMI) are diagnosed with breast cancer at later stages, with greater mortality rates than the general population. Although breast cancer screening is an acknowledged strategy for early breast cancer detection, women with SMI are 32% to 50% less likely to have regular mammography screenings, yet the specific factors related to the disparity in this population have not been determined.

Aim: The purpose of this study was to identify the barriers and facilitators toward breast cancer screening in women diagnosed with SMI.

The Lived Experiences of New Nurses During the COVID-19 Pandemic and Their Contributions to Nursing Education and Professional Development.

Background The COVID-19 pandemic had a major impact on new nurses' transition to the staff nurse role in hospital settings. New staff nurses were not prepared to care for COVID-19 patients based on their previous nursing education. Method A qualitative descriptive design with purposive sampling was used for this study.

Using digital storytelling to understand service users' mental health recovery and address stigma among nursing students.

Purpose: Stigmatized attitudes towards people with mental illness from healthcare providers continues to be a problem affecting recovery in people with mental illness. The process of recovery was explored through digital stories created by service users, with support from nursing students. Stigmatized attitudes in nursing students and stigma resistance in service users were also investigated.

Challenges faced by new nurses during the COVID-19 pandemic.

Introduction: COVID-19 can be considered a unique and complex form of trauma with potentially devastating consequences for nurses in general and new nurses specifically. Few studies have been published that explain how relatively new nurses were prepared for COVID-19 in terms of knowledge and skill and how these nurses fared physically and emotionally.

Design: A qualitative descriptive design utilizing purposive sampling to recruit a diverse group of nurses who were within 2 years post-graduation from nursing school.

Using Mindfulness-Informed Photovoice to Explore Stress and Coping in Women Residing in Public Housing in a Low-Resourced Community.

The setting of the current study was an urban city where the majority of public housing residents are single females living in poverty. An adapted women's mindfulness program, including a Photovoice exercise, was offered to this vulnerable population. Stress contributes to poor mental/physical health.

The Effects of a Community-Based, Multicomponent, Depression Prevention Intervention in Mothers At-Risk.

The purpose of this study was to develop a 12-week multicomponent, depression prevention pilot intervention and evaluate its feasibility and preliminary effects on improving levels and correlates of depressive symptoms, including anger, self-esteem perceived stress, social support, and racism. A quasi-experimental, mixed-methods design and a community-based participatory research (CBPR) approach was employed. University faculty, students and community residents collaborated at a low-income housing complex in a low-resourced, urban community.

The rigid hybrid number for two phylogenetic trees.

Recently there has been considerable interest in the problem of finding a phylogenetic network with a minimum number of reticulation vertices which displays a given set of phylogenetic trees, that is, a network with minimum hybrid number. Such networks are useful for representing the evolution of species whose genomes have undergone processes such as lateral gene transfer and recombination that cannot be represented appropriately by a phylogenetic tree. Even so, as was recently pointed out in the literature, insisting that a network displays the set of trees can be an overly restrictive assumption when modeling certain evolutionary phenomena such as incomplete lineage sorting.

Addressing Ageism and Ethnocultural Diversity With a Photo Essay Project.

Background: By 2050, the percentage of older adults in the United States will double. By 2060, nonmajority individuals will comprise nearly half of our older adult population. Therefore, nursing students must have learning experiences that prepare them to care for a diverse population of older adults when they enter practice.

Caterpillars on three and four leaves are sufficient to reconstruct binary normal networks.

While every rooted binary phylogenetic tree is determined by its set of displayed rooted triples, such a result does not hold for an arbitrary rooted binary phylogenetic network. In particular, there exist two non-isomorphic rooted binary temporal normal networks that display the same set of rooted triples. Moreover, without any structural constraint on the rooted phylogenetic networks under consideration, similarly negative results have also been established for binets and trinets which are rooted subnetworks on two and three leaves, respectively.

The dynamics of geometric PDEs: Surface evolution equations and a comparison with their small gradient approximations.

Apart from three-dimensional continuum and discrete models, the evolution of surfaces is usually described by spatially two-dimensional partial differential equations (PDEs). These models are often derived from or at least motivated by small gradient approximations, but the studied surfaces do not fulfill this requirement in all cases. We will investigate how to overcome the small gradient approximation by using geometric PDEs.

Lost in space? Generalising subtree prune and regraft to spaces of phylogenetic networks.

Over the last fifteen years, phylogenetic networks have become a popular tool to analyse relationships between species whose past includes reticulation events such as hybridisation or horizontal gene transfer. However, the space of phylogenetic networks is significantly larger than that of phylogenetic trees, and how to analyse and search this enlarged space remains a poorly understood problem. Inspired by the widely-used rooted subtree prune and regraft (rSPR) operation on rooted phylogenetic trees, we propose a new operation-called subnet prune and regraft (SNPR)-that induces a metric on the space of all rooted phylogenetic networks on a fixed set of leaves.

On the quirks of maximum parsimony and likelihood on phylogenetic networks.

Maximum parsimony is one of the most frequently-discussed tree reconstruction methods in phylogenetic estimation. However, in recent years it has become more and more apparent that phylogenetic trees are often not sufficient to describe evolution accurately. For instance, processes like hybridization or lateral gene transfer that are commonplace in many groups of organisms and result in mosaic patterns of relationships cannot be represented by a single phylogenetic tree.

Facilitating Social Integration for People With Severe Mental Illness Served by Assertive Community Treatment.

Purpose: This article explores the experience of workers on Assertive Community Treatment (ACT) teams surrounding their efforts to facilitate social integration for their clients.

Design And Methods: Sixteen workers were individually interviewed and eight additional workers participated in two focus groups.

Findings: The formation of caring relationships between worker and client was an important first step towards social integration for ACT clients.

Six-Port Based Interferometry for Precise Radar and Sensing Applications.

Microwave technology plays a more important role in modern industrial sensing applications. Pushed by the significant progress in monolithic microwave integrated circuit technology over the past decades, complex sensing systems operating in the microwave and even millimeter-wave range are available for reasonable costs combined with exquisite performance. In the context of industrial sensing, this stimulates new approaches for metrology based on microwave technology.

Clinical Use of an Autovideography Intervention to Support Recovery in Individuals with Severe Mental Illness.

The current authors introduced an innovative autovideography intervention asking mental health consumers to use video cameras for 1 month to tell about their recovery. The research approach was based on a participatory research model with workers and consumers of a recovery education center fully involved with the study design and implementation. Twelve individuals who had graduated from a recovery program participated.

Autumn Algorithm-Computation of Hybridization Networks for Realistic Phylogenetic Trees.

A minimum hybridization network is a rooted phylogenetic network that displays two given rooted phylogenetic trees using a minimum number of reticulations. Previous mathematical work on their calculation has usually assumed the input trees to be bifurcating, correctly rooted, or that they both contain the same taxa. These assumptions do not hold in biological studies and "realistic" trees have multifurcations, are difficult to root, and rarely contain the same taxa.

Autovideography: The Lived Experience of Recovery for Adults with Serious Mental Illness.

Mental health services have been transforming toward a recovery orientation for more than a decade, yet a robust understanding of recovery eludes many providers, and consensus on a conceptual definition has yet to be reached. This article examines mental health consumers' lived experience of recovery and evaluates the usefulness and comprehensiveness of CHIME, a major framework conceptually defining recovery for adults with serious mental illness. Researchers partnered with a mental health association in a major US city to engage in research with graduates of a recovery and education class for adults diagnosed with serious mental illness.

Spaces of phylogenetic networks from generalized nearest-neighbor interchange operations.

Phylogenetic networks are a generalization of evolutionary or phylogenetic trees that are used to represent the evolution of species which have undergone reticulate evolution. In this paper we consider spaces of such networks defined by some novel local operations that we introduce for converting one phylogenetic network into another. These operations are modeled on the well-studied nearest-neighbor interchange operations on phylogenetic trees, and lead to natural generalizations of the tree spaces that have been previously associated to such operations.

Phylogenetic networks that display a tree twice.

In the last decade, the use of phylogenetic networks to analyze the evolution of species whose past is likely to include reticulation events, such as horizontal gene transfer or hybridization, has gained popularity among evolutionary biologists. Nevertheless, the evolution of a particular gene can generally be described without reticulation events and therefore be represented by a phylogenetic tree. While this is not in contrast to each other, it places emphasis on the necessity of algorithms that analyze and summarize the tree-like information that is contained in a phylogenetic network.

Contact-free scanning and imaging with the scanning ion conductance microscope.

Scanning ion conductance microscopy (SICM) offers the ability to obtain very high-resolution topographical images of living cells. One of the great advantages of SICM lies in its ability to perform contact-free scanning. However, it is not yet clear when the requirements for this scan mode are met.