Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation.

Alveolar bone defect repair remains a persistent clinical challenge for periodontitis treatment. The use of peripheral functional seed cells is a hot topic in periodontitis. Herein, we explored the cellular behaviors and osteogenic ability of adipose-derived mesenchymal stem cells (ADSCs) treated with black phosphorus quantum dots (BPQDs).

Efficacy of venetoclax and rituximab in the treatment of concurrent acute myeloid leukemia and untreated chronic lymphocytic leukemia: A case report and literature review.

To date, few cases of concurrent acute myeloid leukemia (AML) and untreated chronic lymphocytic leukemia (CLL) have been reported. Due to the complexity of the pathogenesis and the absence of a uniform treatment regimen, the associated prognosis remains poor. The present study reports the case of a 58-year-old male with asymptomatic leukocytosis, who was previously healthy with no malignancies.

Zero- to One-Dimensional Zn Supraclusters: Synthesis, Structures and Detection Wavelength.

A zinc supracluster [Zn(ATZ)(AcO)(HO)]·(HO) (), and a 1D zinc supracluster chain {[Zn(ATZ)(AcO)(CHOH)(HO)]·(HO)} () with molecular diameters of 2 nm were synthesized under regulatory solvothermal conditions or the micro bottle method. In an N,N-dimethylformamide solution of , Fe, Ni, Cu, Cr and Co ions exhibited fluorescence-quenching effects, while the rare earth ions Ce, Dy, Er, Eu, Gd, Ho, La, Nd, Sm, and Tbshowed no obvious fluorescence quenching. In ethanol solution, the supracluster can be used to selectively detect Ce ions with excellent efficiency (limit of detection (LOD) = 8.

Venetoclax combined with daunorubicin and cytarabine (2 + 6) as induction treatment in adults with newly diagnosed acute myeloid leukemia: a phase 2, multicenter, single-arm trial.

Background: Venetoclax (Ven) combined with intensive chemotherapy was proven effective in the management of acute myeloid leukemia (AML). However, the severe and prolonged myelosuppression remains a concern to worry about. To explore more appropriate combination regimens, we designed Ven combining daunorubicin and cytarabine (DA 2 + 6) regimen as induction therapy, aimed to evaluate the effectiveness and safety in adults de novo AML.

Transcriptome-wide mA methylome analysis uncovered the changes of mA modification in oral pre-malignant cells compared with normal oral epithelial cells.

As the most common post-transcriptional RNA modification, mA methylation extensively regulates the structure and function of RNA. The dynamic and reversible modification of mA is coordinated by mA writers and erasers. mA reader proteins recognize mA modification on RNA, mediating different downstream biological functions.