Publications by authors named "Linyu Luo"
Article Synopsis
- The study investigates how phosphorylation of AMPKα1 at S485 affects colon cancer cells and identifies PKCα as the responsible kinase.
- The results indicate that S485 phosphorylation is higher in colorectal cancer tissues compared to normal ones and is linked to increased cell growth and migration.
- The research highlights that PKCα plays a key role in this phosphorylation, as its inhibition reduces S485 phosphorylation and impacts cancer cell behaviors under various nutritional conditions.
The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is increasingly common as aging-related diseases. However, little is known about mechanisms responsible for atrial remodeling in AD pathogenesis. α7 nicotinic acetylcholine receptors (α7nAChR) has been shown to have profound effects on mitochondrial oxidative stress in both organ diseases.
View Article and Find Full Text PDFMitochondrial reactive oxygen species (ROS) damage and atrial remodeling serve as the crucial substrates for the genesis of atrial fibrillation (AF). Branched-chain amino acids (BCAAs) catabolic defect plays critical roles in multiple cardiovascular diseases. However, the alteration of atrial BCAA catabolism and its role in AF remain largely unknown.
View Article and Find Full Text PDF