Bioinformatics study of bortezomib resistance-related proteins and signaling pathways in mantle cell lymphoma.

Background: The bortezomib (BTZ) resistance mechanisms in mantle cell lymphoma (MCL) are complex, involving various genes and signaling pathways. This study used bioinformatical tools to identify and analyze differentially expressed genes (DEGs) associated with BTZ resistance.

Methods: Gene chip datasets containing MCL BTZ-resistant and normal control cohorts (GSE20915 and GSE51371) were selected from the Gene Expression Omnibus (GEO) database.

Trace Iron-Doped Nickel-Cobalt selenide with rich heterointerfaces for efficient overall water splitting at high current densities.

Developing bifunctional electrocatalysts based on non-precious metals for overall water splitting, while maintaining high catalytic activity and stability under high current densities, remains challenging. Herein, we successfully constructred trace iron-doped nickel-cobalt selenide with abundant CoSe (210)-NiSe (202) heterointerfaces via a simple one-step selenization reaction. The synthesized Fe-NiCoSe/NCFF (NCFF stands for nickel-cobalt-iron foam) exhibits outstanding hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activity with low overpotentials of 328 mV for HER and 345 mV for OER at a high current density of 1000 mA cm, while maintaining stability for over 20 h.

Oxygen evolution catalyzed by Ni-Co-Nb ternary metal sulfides on plasma-activated Ni-Co support.

As a four-electron-proton coupled reaction, the oxygen evolution reaction (OER) requires a high overpotential for electrocatalytic water splitting. Most of the reported OER catalysts still need higher overpotentials than the thermodynamic water decomposition potential (1.23 V).

Effect of Internet Use to Obtain News on Rural Residents' Satisfaction with the Social Environment: Evidence from China.

The deterioration of satisfaction with the social environment in rural areas recently has become a major issue in the rural governance of China. This study examined if using the Internet to obtain news would affect rural residents' satisfaction with their social environment. It used data from the China Family Panel Studies to determine the influencing factors of rural residents' satisfaction with their social environment in the Internet era.

How Does the Land Rental Market Participation Affect Household Efficiency? Evidence from Rural China.

The active land rental market affects inter-household efficiency. Using nationally representative household panel data in China from 2017 to 2019, we estimate rural household efficiency with consideration of diversification, and analyze the effect of land rental market participation on household efficiency using a control function approach. Results show that: (1) the mean technical efficiency and allocative efficiency were 0.

mA Methyltransferase KIAA1429 Regulates the Cisplatin Sensitivity of Gastric Cancer Cells via Stabilizing FOXM1 mRNA.

Although cisplatin is frequently used to treat gastric cancer, the resistance is the main obstacle for effective treatment. mRNA modification, N6-methyladenosine (mA), is involved in the tumorigenesis of many types of cancer. As one of the largest mA methyltransferase complex components, KIAA1429 bridges the catalytic mA methyltransferase components, such as METTL3.

A benchmark study of deep learning-based multi-omics data fusion methods for cancer.

Background: A fused method using a combination of multi-omics data enables a comprehensive study of complex biological processes and highlights the interrelationship of relevant biomolecules and their functions. Driven by high-throughput sequencing technologies, several promising deep learning methods have been proposed for fusing multi-omics data generated from a large number of samples.

Results: In this study, 16 representative deep learning methods are comprehensively evaluated on simulated, single-cell, and cancer multi-omics datasets.

Impact of the participation of rural households in the appraisal on poor households' identification.

Developing countries have common goals of poverty eradication and improving people's livelihoods. As the largest developing country, China has made remarkable achievements in poverty alleviation during the 30 years of reform. Although a targeted poverty alleviation mechanism was established by the Chinese government in 2013, the identification of poor households has been an arduous journey.

mA methyltransferase KIAA1429 acts as an oncogenic factor in colorectal cancer by regulating SIRT1 in an mA-dependent manner.

N6-methyladenosine (m6A) modifications of RNAs are involved in various aspects of colorectal carcinogenesis via regulation of mRNA stability, splicing, and translation. KIAA1429, an m6A methyltransferase, was found deregulated in multiple cancer types. However, its role in colorectal cancer remains elusive.

Computed Tomographic Studies of Noncalcified Nodules Related to Neuroendocrine Lung Tumor Using 68Gallium-Tagged Somatostatin Variant for Improvement in Diagnosis: A Non-Experimental, Non-Randomized, Cross-Sectional Study.

BACKGROUND 18Fluoro-fluorodeoxyglucose (FDG)- based positron-emission computed tomography (PET) has less specificity for noncalcified nodules (NNs). Somatostatin receptors affect the expression of normal and malignant cells. The purpose of the study was to compare the sensitivity, specificity, and accuracy of 68Gallium-tagged DOTA-octreotate (Ga-tDO) with that of FDG PET for diagnosis of newly detected and/or untreated NNs in lung cancer patients.

In Vivo Therapeutic Effect of Vaccinium Meridionale Swartz in Ischemia-Reperfusion Induced Male Albino Rats.

This study was aimed to investigate the cardioprotective and antioxidant effect of Vaccinium meridionale Swartz in ischemia-induced male albino Wistar strain rats. Rats were grouped into 5 of 6 numbers each. Group I served as a sham, group II served as control and group III, IV, and V served for 1, 10, and 25 mg/kg/d of an extract of Vaccinium meridionale Swartz for 15 consecutive days of treatment.