A bismuth-based double-network hydrogel-mediated synergistic photothermal-chemodynamic therapy for accelerated wound healing.

Multidrug-resistant bacterial infections present a significant challenge to wound healing. Non-antibiotic approaches such as photothermal therapy (PTT) and chemodynamic therapy (CDT) are promising but have suboptimal anti-bacterial efficacy. Herein, we developed a green bismuth-based double-network hydrogel (Bi@P-Cu) as a PTT/CDT synergistic platform for accelerated drug-resistant bacteria-infected wound healing.

MnCO@BSA-ICG nanoparticles as a magnetic resonance/photoacoustic dual-modal contrast agent for functional imaging of acute ischemic stroke.

Timely and accurate diagnosis of acute ischemic stroke (AIS) and simultaneous functional imaging of cerebral oxygen saturation (sO) are essential to improve the survival rate of stroke patients but remains challenging. Herein, we developed a pH-responsive manganese (Mn)-based nanoplatform as a magnetic resonance/photoacoustic (MR/PA) dual-modal contrast agent for AIS diagnosis. The Mn-based nanoplatform was prepared via a simple and green biomimetic method using bovine serum albumin (BSA) as a scaffold for fabrication of MnCO NPs as the T MR contrast agent and accommodation of indocyanine green (ICG) as the PA probe.

Application of Rapid Rehabilitation Surgical Nursing Combined With Continuous Nursing in Self-Care Ability, Medication Compliance and Quality of Life of Renal Transplant Patients.

Objective: To explore the effects of rapid rehabilitation surgery (FTS) nursing combined with continuous nursing on self-care ability, medication compliance and quality of life of patients after renal transplantation.

Methods: Sixty patients who received kidney transplantation in our hospital from January 2019 to January 2021 were randomly divided into the control group and the observation group with 30 patients in each group according to the random number table method. The control group was given FTS nursing, while the observation group was given continuous nursing on the basis of the control group.

PbLAC4-like, activated by PbMYB26, related to the degradation of anthocyanin during color fading in pear.

Background: Decrease in anthocyanin content results in the loss of red color in leaves, petals and receptacles during development. The content of anthocyanin was affected by the biosynthesis and degradation of anthocyanin. Compared with the known detailed mechanism of anthocyanin biosynthesis, the degradation mechanism is not fully investigated.

PbEIL1 acts upstream of PbCysp1 to regulate ovule senescence in seedless pear.

Numerous environmental and endogenous signals control the highly orchestrated and intricate process of plant senescence. Ethylene, a well-known inducer of senescence, has long been considered a key endogenous regulator of leaf and flower senescence, but the molecular mechanism of ethylene-induced ovule senescence has not yet been elucidated. In this study, we found that blockage of fertilization caused ovule abortion in the pear cultivar '1913'.

PbMYB120 Negatively Regulates Anthocyanin Accumulation in Pear.

Subgroup 4 R2R3 MYBs play vital roles in the regulation of anthocyanin biosynthesis. However, there is limited knowledge regarding the functions of MYB repressors in pear (). Here, PbMYB120 was identified as a potential regulator of anthocyanin biosynthesis.

Differences among the Anthocyanin Accumulation Patterns and Related Gene Expression Levels in Red Pears.

Differences in coloration exist among red pear cultivars. Here, we selected six red pear cultivars with different genetic backgrounds to elucidate the characteristics of fruit pigmentation. We detected anthocyanin contents and the expression levels of anthocyanin synthesis-related genes in these cultivars at different stages of fruit development.

PbCOP1.1 Contributes to the Negative Regulation of Anthocyanin Biosynthesis in Pear.

The synthesis of anthocyanin in pear () fruit is regulated by light. However, little is known about the molecular mechanisms of pear fruit coloring mediated by upstream light-signaling regulators. Here, the photoresponse factors CONSTITUTIVE PHOTOMORPHOGENIC (COP) 1.

Transcriptome Analysis Reveals Candidate Genes Related to Color Fading of 'Red Bartlett' ( L.).

The red color of fruit is an attractive plant trait for consumers. Plants with color-faded fruit have a lower commercial value, such as 'Red Bartlett' pears ( L.) that have dark-red fruit in the early stages of fruit development that subsequently fade to red-green at maturity.

Two MYB transcription factors regulate flavonoid biosynthesis in pear fruit (Pyrus bretschneideri Rehd.).

Flavonoid compounds play important roles in the modern diet, and pear fruits are an excellent dietary source of these metabolites. However, information on the regulatory network of flavonoid biosynthesis in pear fruits is rare. In this work, 18 putative flavonoid-related MYB transcription factors (TFs) were screened by phylogenetic analysis and four of them were correlated with flavonoid biosynthesis patterns in pear fruits.

Protein A immunoadsorption therapy in the highly sensitized kidney transplant candidates.

Background: Sensitization in transplant candidates increases risk of irreversible immunologic injury of graft in the early period postoperatively. Elimination of anti-human leukocyte antigen (HLA) antibodies using protein A immunoadsorption (IA) might benefit these patients.

Methods: Protein A IA was used in 21 patients with high panel reactive antibody (PRA).