Publications by authors named "Linxue Meng"
Article Synopsis
- The study investigates the safety of Nusinersen, an FDA-approved drug for Spinal Muscular Atrophy, using the FAERS database to analyze adverse events.
- It employs various statistical models to identify Nusinersen-related adverse reactions, finding 230 new adverse terms and highlighting potential side effects like cardiac arrest and autism spectrum disorder.
- The findings suggest that younger patients may face risks of upper respiratory infections, while older patients could show symptoms of post-lumbar puncture syndrome, underscoring the need for careful monitoring.
Article Synopsis
- Rufinamide (RUF) is a new antiepileptic drug used for Lennox-Gastaut syndrome, but its side effects are not fully understood, prompting a study to assess its safety.
- The research involved analyzing 338 adverse drug event reports, identifying nervous system disorders and several new adverse effects such as atonic seizures and sudden unexplained deaths.
- The study concluded that RUF is associated with significant risks, leading to increased awareness among prescribers and patients regarding its potential adverse effects.
Hypertension is prevalent in e-waste recycling areas, and elevated blood pressure in children significantly increases the risk of hypertension in adulthood. However, the associations and toxic pathways between chronic exposure to metal(loids) and elevated blood pressure are rarely investigated. In this study, we measured the levels of 29 hair metal(loids) (chronic exposure biomarkers) and blood pressure in 667 susceptible children from an e-waste recycling area to explore their relationships.
View Article and Find Full Text PDFBackground: Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), the underlying causative genes and biological mechanisms remain predominantly elusive.
Methods: The FinnGen R10 dataset, consisting of 333,711 subjects (20,908 cases and 312,803 controls), was utilized in conjunction with the Genotype-Tissue Expression Project (GTEx) v8 EQTls files to conduct cross-tissue transcriptome association studies (TWAS).
Epidemiological studies have established a robust correlation between exposure to ambient particulate matter (PM) and various neurological disorders, with dysregulation of intracellular redox processes and cell death being key mechanisms involved. Ferroptosis, a cell death form characterized by iron-dependent lipid peroxidation and disruption of antioxidant defenses, may be involved in the neurotoxic effects of PM exposure. However, the relationship between PM-induced neurotoxicity and ferroptosis in nerve cells remains to be elucidated.
View Article and Find Full Text PDFBackground: Sleep apnea is regarded as a significant global public health issue. The relationship between sleep apnea and nervous system diseases is intricate, yet the precise mechanism remains unclear.
Methods: In this study, we conducted a comprehensive analysis integrating the human brain proteome and transcriptome with sleep apnea genome-wide association study (GWAS), employing genome-wide association study (PWAS), transcriptome-wide association study (TWAS), Mendelian randomization (MR), and colocalization analysis to identify brain proteins associated with sleep apnea.
Purpose: This study reported the first case of Kohlschütter-Tönz syndrome (KTS) in China and reviewed the literature of the reported cases.
Methods: This patient was registered at the Children's Hospital of Chongqing Medical University. The patient's symptoms and treatments were recorded in detail, and the patient was monitored for six years.
Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis, mainly impacting young females and children. The involvement of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome and related cytokines in pediatric individuals with this condition remains unclear.
Methods: We collected information from 27 children who had anti-NMDAR encephalitis and 12 individuals with non-inflammatory neurological disorders as controls.
Article Synopsis
- The study focused on analyzing seizure characteristics in children with Japanese encephalitis (JE) and identifying risk factors for developing postencephalitic epilepsy (PEE).
- A total of 328 hospitalized children were examined, revealing that 65.9% experienced seizures during the acute phase, with a PEE incidence of 14.7% post-discharge.
- Key risk factors for PEE included having more than five seizures, status epilepticus, and coma, leading to the development of a predictive model and a visualization tool (nomogram) that demonstrated good accuracy in risk prediction.
Objective: We aimed to develop a predictive nomogram for the early detection of hydrocephalus in children with bacterial meningitis.
Methods: This retrospective study was based on data of children with bacterial meningitis admitted to our hospital between January 2016 and December 2020. Risk factors were evaluated using univariate analysis, and the predictive model/nomogram was built using binary logistic analysis.