ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM.

When the alkali reserve is artificially lowered in rats infected with Trypanosoma lewisi, the number of parasites in the blood is increased. The increase is large in the early stages of the disease, and becomes less marked as the number crisis is approached. Near the crisis, and after it, a lowered alkali reserve does not affect the number of trypanosomes.

BLOOD CHEMICAL CHANGES IN EXPERIMENTAL STREPTOCOCCUS SEPTICEMIA.

The following changes have been found to occur in rabbits given fatal intravenous doses of Streptococcus hemolyticus: The blood sugar concentration drops at a constant rate throughout the disease, but does not reach a condition of hypoglycemia. Glycogen is present in the liver at death. The CO(2) capacity is lowered markedly at first, then returns to a somewhat higher level, at which it continues until the terminal stage of the disease, when the acidosis becomes very marked.

A COMPARISON OF THE CHEMICAL ALTERATIONS IN THE BLOOD OF RATS INFECTED WITH PATHOGENIC AND NON-PATHOGENIC TRYPANOSOMES.

Blood samples from rats infected with Trypanosoma lewisi give normal values for lipoid phosphorus, lecithin, CO(2) combining capacity, and liver glycogen. When these results are compared with the results of similar experiments with T. equiperdum infections, on the basis of the concentration of trypanosomes in the blood, it is found that the pathogenicity of the latter organism does not depend upon its numbers as affecting the blood, but that it must be in some other way injurious to the host.

THE BLOOD CHEMISTRY OF AN ACUTE TRYPANOSOME INFECTION.

The CO(2) capacity of the serum is markedly lowered early in infection with Trypanosoma equiperdum. The non-protein nitrogen and uric acid constituents of the blood are increased in the terminal stages. The kidneys also show terminal degenerative changes.