Publications by authors named "Lintel M"
Objective: To compare pathology results after office-based blind endometrial biopsy and pathology results from hysteroscopy in women presenting with abnormal uterine bleeding (AUB).
Methods: A retrospective cohort study of biologic women presenting with AUB at a tertiary care referral care center. Patients were included if they underwent evaluation with blind endometrial biopsy performed in the office followed by hysteroscopy within one year.
Background: Prenatal genetic screens, including carrier screening (CS) and aneuploidy screening (AS), comprise an important component of reproductive healthcare delivery. Clinical practice guidelines emphasize the importance of informed decision-making and patient's preferences regarding the use of these screens. Yet, it is unclear how to achieve this ideal as prenatal genetic screening options rapidly become more complex and increasingly available to patients.
View Article and Find Full Text PDFSynchronous Bilateral Lung Cancer With Discordant Histology.
Oncology (Williston Park)
February 2020
Synchronous multiple primary lung cancer (SMPLC) is a rare occurrence affecting 0.5% to 2% of patients with lung cancer. Synchronous discordant histology with small cell and non-small cell lung carcinoma is an even less common entity.
View Article and Find Full Text PDFIn the original version of this article the authors noted that the GEO accession number for the relevant dataset was listed incorrectly as GSE12454.
View Article and Find Full Text PDFArticle Synopsis
- MTG16 is a corepressor protein that interacts with Kaiso to regulate specific target genes, influencing inflammation and tumor development in cancer.
- Research using a mouse model of colitis-associated cancer showed that loss of MTG16 worsens tumor growth, while loss of Kaiso in MTG16-deficient mice surprisingly reduced tumor burden back to normal levels.
- The study's findings suggest that Kaiso plays a crucial role in modifying the effects of MTG16 loss on inflammation and tumorigenesis, indicating that the regulation of these proteins could be important in understanding and potentially treating related cancers.
Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is essential for selenoprotein production and is transported from the liver to target tissues via selenoprotein P (SEPP1).
View Article and Find Full Text PDFArticle Synopsis
- - Selenium (Se) is a crucial micronutrient that impacts inflammatory bowel disease (IBD) through selenoproteins, with studies suggesting that lower Se levels correlate with increased severity of IBD and colon cancer risks.
- - Research involving mice showed that those deficient in Se experienced more severe colonic injuries and higher DNA damage in response to DSS-induced colitis, along with increased inflammation-related cytokines.
- - In a cancer model combining AOM and DSS, Se-deficient mice developed more tumors, indicating that Se deficiency not only exacerbates IBD but also plays a role in the initiation and progression of colitis-associated cancer (CAC).