Publications by authors named "Linrui R Guo"

During cardiac surgery with cardiopulmonary bypass (CPB), adequate maintenance of cerebral blood flow (CBF) is vital in preventing postoperative neurological injury - i.e. stroke, delirium, cognitive impairment.

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Article Synopsis
  • Pulsatile perfusion during cardiopulmonary bypass (CPB) may enhance microcirculation compared to traditional nonpulsatile methods, as evidenced by a study involving high-risk cardiac patients.
  • The study measured microcirculatory characteristics and tissue oxygen saturation at various time points during and after CPB, revealing that the pulsatile group maintained better blood flow and perfusion.
  • Overall, the findings suggest that pulsatile flow can lead to better recovery of microvascular function and potentially reduce complications related to systemic inflammation and reperfusion injury.
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Objective: Aortic valve replacement is the standard of care for severe, symptomatic aortic valve stenosis (AS); however, anatomy or pre-existing comorbidities may preclude conventional or alternative transcatheter approaches. Aortic valve bypass (AVB) may be performed as a salvage procedure for the relief of symptomatic aortic stenosis in patients who are not suitable candidates for aortic valve replacement.

Methods: At our institution, seven patients underwent AVB using the Correx automated coring and apical connector system.

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Background: Controversy exists regarding the optimal perfusion modality during cardiopulmonary bypass (CPB). Here we compare the effects of pulsatile versus nonpulsatile perfusion on microvascular blood flow during and after CPB.

Methods: High-risk cardiac surgical patients were randomly assigned to have pulsatile (n=10) or nonpulsatile (n=10) flow during CPB.

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Purpose: The technical difficulty of performing the left ventricular apical anastomosis has limited the adoption of aortic valve bypass surgery for the treatment of aortic stenosis. We report the successful use of an automated coring and apical connector device to perform aortic valve bypass surgery.

Description: A 74-year-old man, with a history of prior coronary bypass surgery with patent grafts and a porcelain ascending aorta, presented with symptomatic critical aortic stenosis.

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Myocardial infarction that is attributed to native coronary artery spasm in the early postoperative phase has rarely been documented. We report three cases of postoperative myocardial infarction secondary to angiographically demonstrated coronary spasm. Native coronary artery spasm is a rare, but important cause of postoperative ischemia and infarction.

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