Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study.

Objective: This study aims to investigate the genetic link between psoriasis and sudden sensorineural hearing loss (SSNHL).

Methods: From a genetic standpoint, this study further highlighted the connection between psoriasis and SSNHL. Single nucleotide polymorphisms (SNPs) connected to SSNHL could be found using a genome-wide association study from the IEU OpenGWAS project website.

Effect of school entrance age on myopia among primary schoolchildren using mixed-effect model: The Shantou Myopia Study (SMS).

Purpose: To investigate the association between children's school entrance age and refractive status and prevalence of myopia in southern China.

Methods: Population-based Cross-sectional study was conducted from September 2020 to June 2021 in Shantou, southern China, enrolling primary schoolchildren in the city. The school entrance age was calculated as the months from the birth date to the entrance date, divided by 12.

Exploring Programmed Cell Death-Related Biomarkers and Disease Therapy Strategy in Nasopharyngeal Carcinoma Using Transcriptomics.

Background: Uncontrolled cellular proliferation may result in the progression of diseases such as cancer that promote organism death. Programmed cell death (PCD) is an important mechanism that ensures the quality and quantity of cells, which could be developed as a potential biomarker for disease diagnosis and treatment.

Methods: RNA-seq data and clinical information of nasopharyngeal carcinoma (NPC) patients were downloaded from the Gene Expression Omnibus (GEO), and 1548 PCD-related genes were collected.

Mendelian Randomization Study Reveals a Predicted Relationship between Sensorineural Hearing Loss and Mitochondrial Proteins.

Background: Mitochondrial proteins assume a pivotal role in the onset and progression of diverse diseases. Nonetheless, the causal interconnections with sensorineural hearing loss (SNHL) demand meticulous exploration. Mendelian randomization analysis is a method used in observational epidemiological studies to predict the relationship between exposure factors and outcomes using genetic variants as instrumental variables.

Exosome-Mediated Transfer of ALDH2 in Nasopharyngeal Carcinoma Cells Confers Increased Resistance to Paclitaxel Treatment.

Background: Nasopharyngeal carcinoma (NPC) is an aggressive and highly metastatic malignant tumor. Despite recent therapeutic advances, resistance to Taxol (the generic name of paclitaxel) therapy remains a major challenge in clinical management. Therefore, it is imperative to explore the potential mechanisms of paclitaxel resistance in NPC.

Antimicrobial poly (1,4-butylene carbonate): Preparation, characterization, and potential applications as a material for tympanic membrane repair.

Perforation of the tympanic membrane (TM) is a common condition that often requires a scaffold as a support for surgery. However, because of the external environment of the auditory canal, the scaffold could become bacterially infected and prevent the TM from healing. As a result, the perfect scaffold should have both antibacterial and biomimetic qualities.

The Association Between Stress and Symptomatic Tinnitus: A Preliminary Study.

Tinnitus can severely impair people's quality of life. Stress has been involved in the pathogenesis of multiform mental disorders. Tinnitus-related annoying symptoms have a negative effect on the life quality of tinnitus sufferers.

Stabilized O3-Type Layered Sodium Oxides with Enhanced Rate Performance and Cycling Stability by Dual-Site Ti /K Substitution.

High-capacity O3-type layered sodium oxides are considered one of the most promising cathode materials for the next generation of Na-ion batteries (NIBs). However, these cathodes usually suffer from low high-rate capacity and poor cycling stability due to structure deformation, native air sensitivity, and interfacial side reactions. Herein, a multi-site substituted strategy is employed to enhance the stability of O3-type NaNi Mn O .

Implementing interventions to promote spectacle wearing among children with refractive errors: A systematic review and meta-analysis.

Purpose: To investigate the level of compliance of children with refractive errors who are provided free spectacles, and to identify the reasons for non-compliance.

Methods: We systematically searched the PubMed, EMBASE, CINAHL, Web of Science, and Cochrane Library databases from the time these databases were established to April 2022, including studies published in English. The search terms were "randomized controlled trial" [Publication Type] OR "randomized" [Title/Abstract], OR "placebo" [Title/Abstract]) AND (("Refractive Errors"[MeSH Terms] OR ("error refractive" [Title/Abstract] OR "errors refractive" [Title/Abstract] OR "refractive error" [Title/Abstract] OR "refractive disorders" [Title/Abstract] OR "disorder refractive" [Title/Abstract] OR "disorders refractive" [Title/Abstract] OR "refractive disorder" [Title/Abstract] OR "Ametropia" [Title/Abstract] OR "Ametropias" [Title/Abstract])) AND ("Eyeglasses" [MeSH Terms] OR ("Spectacles" [Title/Abstract] OR "Glasses"[Title/Abstract]) AND ("Adolescent" [MeSH Terms] OR ("Adolescents" [Title/Abstract] OR "Adolescence"[Title/Abstract]) OR "Child"[MeSH Terms] OR "Children"[Title/Abstract])).

An empirical study on the asset-light operation and corporate performance of China's tourism listed companies.

Transitioning to an asset-light strategy is a significant shift for tourism companies in light of the global COVID-19 outbreak. This study investigates the impact of asset-light strategy on corporate performance using a sample of 588 firm-year observations from China A-share publicly traded tourism companies from 2003 to 2021. Using two-way fixed effects models, our results indicate that adopting an asset-light strategy can significantly improve the performance of tourism enterprises.

Arylsulfatase I is a prognostic biomarker for head and neck squamous cell carcinoma and Pan-cancer.

Background: Sulfatase gene family members mediate various biological functions in tumor stroma and tumor cell environments. However, the expressions and prognostic value of Arylsulfatase I (ARSI), a sulfatase gene family member, in head and neck squamous cell carcinoma (HNSC) have not been fully established.

Methods: Arylsulfatase I expressions in pan-cancer were profiled using publicly available databases.

Survival of cancer patients in Fujian, Southeast China: a population-based cancer registry study.

Survival rates are usually used to evaluate the effect of cancer treatment and prevention. No study has focused on the characteristic of population-based cancer survival in Fujian, which is regarded as one of the high-risk areas of cancer in China. This study aims to analyze the 5-year relative survival of patients in Fujian Province using population-based cancer registry data.

Dysregulated Expression Levels of Circular RNAs Serve as Prognostic and Clinicopathological Markers in Gastric Cancer: a Meta-Analysis.

Background: Circular RNAs (circRNAs) are novel biomarkers that are widely investigated in various cancers. There is increasing evidence that the expression levels of circRNAs are upregulated or downregulated in various cancers, but the overall prognostic efficiency of circRNAs in gastric cancer (GC) remains unclear. Therefore, this meta-analysis studies the relationship between circRNA expression and the prognosis of gastric malignancies.

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis.

Background: Tympanic membrane (TM) perforation is quite common in the clinical setting. Chronic TM perforations require surgical treatments such as myringoplasty. Currently, platelet-rich plasma (PRP) is a novel, effective substance that is increasingly utilized for TM perforation repair.

Expression of the long noncoding RNA RP11-169D4.1-001 in Hypopharyngeal Squamous cell carcinoma tissue and its clinical significance.

Background: Increased research efforts have demonstrated that lncRNAs are associated with multiple head and neck tumors and play important roles in cancer. We previously found that RP11-169D4.1-001 plays a tumor-suppressive role in laryngeal cancer, but its function in human hypopharyngeal squamous cell carcinoma (HSCC) remains unknown.

Distribution of virulence-associated genes and antimicrobial susceptibility in clinical isolates.

is undoubtedly one of the most clinically significant pathogens. The multidrug resistance and virulence potential of are responsible for hospital-acquired nosocomial infections. Unlike numerous investigations on the drug-resistant epidemiology of , virulence molecular epidemiology is less studied.