The alleviating effect on the growth, chlorophyll synthesis, and biochemical defense system in sunflowers under cadmium stress achieved through foliar application of humic acid.

Background: With the progress of industrialization and urbanization, cadmium (Cd) pollution in farmland is increasingly severe, greatly affecting human health. Sunflowers possess high resistance to Cd stress and great potential for phytoremediation of Cd-contaminated soil. Previous studies have shown that humic acid (HA) effectively mitigates plant damage induced by Cd; however, its alleviating effects on sunflower plants under Cd stress remain largely unknown.

CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection by targeting ORF6 for ubiquitin-dependent degradation.

The accessory protein ORF6 of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key interferon (IFN) antagonist that strongly suppresses the production of primary IFN as well as the expression of IFN-stimulated genes. However, how host cells respond to ORF6 remains largely unknown. Our research of ORF6-binding proteins by pulldown revealed that E3 ligase components such as Cullin 4B (CUL4B), DDB1, and RBX1 are potential ORF6-interacting proteins.

Deubiquitinase USP39 promotes SARS-CoV-2 replication by deubiquitinating and stabilizing the envelope protein.

The SARS-CoV-2 envelope (E) protein is highly conserved among different viral variants and important for viral assembly and production. Our recent study found that the E protein is ubiquitinated and degraded by the E3 ligase RNF5 through the proteasome pathway. However, whether E ubiquitination can be reversed by host deubiquitinase has not yet been determined.

Living Alone but Not Feeling Lonely: The Effect of Self-Concealment on Perceived Social Support of Youth Living Alone in China.

The current study explored the mechanism of self-concealment on perceived social support among youth living alone and tried to clarify the two mediating variables, which are "psychological needs met through internet gratification" and "social self-esteem", by using the Self-Concealment Scale, the Psychological Needs met through Internet Gratification Scale, the Texas Social Behavior Inventory and the Perceived Social Support Scale. Four hundred thirty-three working youth living alone who have lived alone or shared no emotional intersection with others were chosen as participants in this study. The results showed that: (1) the correlation between self-concealment, perceived social support, psychological needs met via internet gratification and social self-esteem was significant; (2) self-concealment positively predicted perceived social support; (3) self-concealment indirectly predicted perceived social support through the chain mediating effect of "psychological needs met via internet gratification" and "social self-esteem".

Correction to: Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection.

In Fig. 2B, labels were misnamed in the original article. MVC label and MVC + OMT label were opposite.

Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection.

Oxymatrine (OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties, including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on parvovirus infection have yet to be reported. In the present study, we investigated the effects of OMT on cell viability, virus DNA replication, viral gene expression, cell cycle, and apoptosis in Walter Reed canine cells/3873D infected with minute virus of canines (MVC). OMT, at concentrations below 4 mmol/L(no cellular toxicity), was found to inhibit MVC DNA replication and reduce viral gene expression at both mRNA and protein levels, which was associated with the inhibition of cell cycle S-phase arrest in early-stage of MVC infection.