Gadolinium(III) Porphyrinoid Phototheranostics.

Molecular phototheranostics as an emerging field of modern precision medicine has recently attracted increasing research attention owing to non-invasiveness, high precision, and controllable nature of light. In this work, we reported promising gadolinium (Gd ) porphyrinoids as phototheranostic agents for magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The synthesized Gd-1-4-Glu featured with meso-glycosylation and β-lactonization to endow good biocompatibility and improved photophysical properties.

Near-infrared laser-triggered drug release in a tellurium nanosystem for simultaneous chemo-photothermal cancer therapy.

Tumor cells can be selectively killed by heat application based on the different tolerances of normal cells and tumor cells to temperature. However, the limited clinical application of photothermal therapy (PTT) is mainly due to various practical implementation difficulties, of which the most important is how to fully heat the tumor. The combination of PTT and chemotherapy can synergistically enhance cell membrane permeability and reduce the dose of chemotherapy drugs to not only effectively kill the tumor but also reduce the damage to normal tissues.

A highly hemocompatible erythrocyte membrane-coated ultrasmall selenium nanosystem for simultaneous cancer radiosensitization and precise antiangiogenesis.

Radiotherapy is a vitally important strategy for clinical treatment of malignant cancers. Therefore, rational design and development of radiosensitizers that could enhance radiotherapeutic efficacy has attracted tremendous attention. Antiangiogenesis therapy could be a potentially effective strategy to regulate tumor growth and metastasis due to angiogenesis plays a pivotal role for tumor growth, invasion and metastasis to other organs.