Publications by authors named "Linnea Schuez-Havupalo"
Background: Only a few previous studies examine immune system recovery after completed cancer treatment.
Aims: The aim of this study was to analyze immune reconstitution after childhood cancer therapy in a non-hematopoietic stem cell transplantation setting.
Methods And Results: We analyzed children (N = 79) who received chemotherapy with/without irradiation for cancer diagnosed between 2014 and 2019 at Turku University Hospital, Finland.
Objectives: Although the airway microbiota is a highly dynamic ecology, the role of longitudinal changes in airway microbiota during early childhood in asthma development is unclear. We aimed to investigate the association of longitudinal changes in early nasal microbiota with the risk of developing asthma.
Methods: In this prospective, population-based birth cohort study, we followed children from birth to age 7 years.
Background: Early-life exposures to antibiotics may increase the risk of developing childhood asthma. However, little is known about the mechanisms linking antibiotic exposures to asthma. We hypothesized that changes in the nasal airway microbiota serve as a causal mediator in the antibiotics-asthma link.
View Article and Find Full Text PDFObjectives: Respiratory syncytial virus (RSV) is a major cause of hospitalization in young children, but there are little data on RSV infections in early childhood in the community. We conducted a prospective population-based birth-cohort study to determine the rates and characteristics of RSV infections in young children.
Methods: We followed 923 children for acute respiratory infections (ARIs) from birth to age 24 months with daily diaries and study clinic visits.
Background: Pneumococcal conjugate vaccines reduce the incidence of invasive pneumococcal diseases, pneumonia, acute otitis media (AOM), and antimicrobial prescriptions in children. We investigated the effectiveness of at least one dose of the ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10; GSK) against respiratory tract infections (RTIs) in children under two years of age.
Methods: 424 children enrolled in a cluster-randomized, double-blind Finnish Invasive Pneumococcal disease (FinIP) vaccine trial during the years 2009-2010 were actively followed in a prospective cohort study (STEPS study) for RTIs from birth to two years of age.
Background: An association between maternal prenatal stress and increased rates of respiratory tract infections in the offspring has been described earlier. Data regarding the father's role is lacking. In this study our aim was to evaluate, whether mothers' and fathers' depressive symptoms and loneliness during pregnancy predict higher rates of respiratory tract infections in the offspring.
View Article and Find Full Text PDFInfluenza virus infections from 0 to 2 years of age: A birth cohort study.
J Microbiol Immunol Infect
August 2019
Background/purpose: Influenza vaccine has been recommended in Finland since 2007 for all children of 6-35 months of age and in 2009 for those ≥6 months against pandemic influenza. We investigated the incidence of influenza and vaccine effectiveness in a birth cohort of children in 2008-2011.
Methods: We followed 923 children from birth to 2 years of age for respiratory tract infections.
Objective: We explored the burden of respiratory tract infections (RTIs) in young children with regard to day-care initiation.
Design: Longitudinal prospective birth cohort study.
Setting And Methods: We recruited 1827 children for follow-up until the age of 24 months collecting diary data on RTIs and daycare.
Rationale: Laboratory and clinical evidence suggests synergy between rhinoviruses and Streptococcus pneumoniae in the pathogenesis of respiratory tract infections. However, it is unclear whether rhinoviruses promote pneumococcal acquisition and transmission.
Objectives: To describe the impact of rhinovirus infection on the acquisition and transmission of pneumococci within families with children.
Background And Objectives: Rhinoviruses frequently cause respiratory infections in young children. We aimed to establish the burden of acute respiratory infections caused by rhinovirus during the first 2 years of life.
Methods: In this prospective birth cohort study, we followed 923 children for acute respiratory infections from birth to 2 years of age.
Background: The burden of recurrent respiratory infections is unclear. We identified young children with recurrent respiratory infections in order to characterize the clinical manifestations, risk factors and short-term consequences.
Methods: In this prospective cohort study, 1089 children were followed from birth to 2 years of age for respiratory infections by a daily symptom diary.
Background: Type I interferon induced MxA response can differentiate viral from bacterial infections, but MxA responses in rhinovirus or asymptomatic virus infections are not known.
Objective: To study MxA protein levels in healthy state and during respiratory virus infection of young children in an observational prospective cohort.
Study Design: Blood samples and nasal swabs were collected from 153 and 77 children with and without symptoms of respiratory infections, respectively.
Aim: Infant swimming has been considered as a risk factor for wheezing, but the role that respiratory viruses play is unclear. We explored the effects of infant swimming on the risk of all wheezing illnesses and wheezing associated with rhinoviruses.
Methods: We followed up a birth cohort of 1827 children until 17 months of age, collecting data on infant swimming, other risk factors and physician-diagnosed bronchiolitis or recurrent wheezing.