Publications by authors named "Linna Xie"

Organic films containing unsaturated lipids are widespread, yet their oxidation pathways with associated impacts on contaminant lifetimes and human exposure remain poorly explored under indoor environmental conditions. This study demonstrates that UVA radiation and radical exposure drive rapid autoxidation of thin films of methyl linolenate (ML) and canola oil (which contains polyunsaturated triglycerides), primarily producing organic hydroperoxides. For ML films this fast chemistry occurs at the same rate under entirely dark, genuine indoor conditions as it does when the films are exposed to significantly higher OH radicals in a flow reactor.

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It is well known that hydroxyl radical (OH) can be largely produced either through the classic iron-mediated inorganic-Fenton system or our recently discovered haloquinones/HO organic-Fenton-like system, but rarely produced via thiol compounds. Here, unexpectedly, we found that OH can be unequivocally generated by incubation of HO and mercaptotriazole (MTZ), a typical heterocyclic thiol which has been used as an environmentally friendly corrosion inhibitor for mild steel. By the complementary applications of HPLC-MS and oxygen-18 isotope-labeling method, MTZ-derived sulfenic (MTZ-SOH) and sulfinic acids were detected and identified as transient intermediates, and sulfonic acid as final products.

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Objective: Patients with hematological malignancies have an elevated risk of developing pneumonia after contracting COVID-19. Lymphoma is the most prevalent hematologic malignancy. It is critical to identify patients at high risk of contracting COVID-19-associated pneumonia.

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Haloacetonitriles (HANs) are a class of toxic drinking water disinfection byproducts (DBPs). However, the toxicity mechanisms of HANs remain unclear. We herein investigated the structure-related in vitro toxicity of 6 representative HANs by utilizing complementary bioanalytical approaches.

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Background: Double-expressor lymphoma (DEL) has a poorer prognosis than other subtypes of diffuse large B-cell lymphoma (DLBCL). This study is a multicenter, prospective, single-arm, phase 2 clinical study initiated by investigators to evaluate the efficacy and safety of combined zanubrutinib with R-CHOP, which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone for patients with DEL (stage II or more), as well as to explore factors related to efficacy preliminarily.

Methods: From November 2020 to July 2022, 48 newly diagnosed patients were enrolled.

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Background: Oligoasthenoteratozoospermia (OAT) is a widespread cause of male infertility. One of the usual clinical manifestations of OAT is multiple morphological abnormalities of the sperm flagella (MMAF), which are frequently associated with mutations and defects in the dynein family. However, the relationship between the newly identified Dynein Axonemal Heavy Chain 3 (DNAH3) mutation and oligonasthenospermia in humans has not yet been established.

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Background: Acute graft-versus-host disease (aGVHD) is a common complication after allogeneic hematopoietic cell transplantation (allo-HSCT), with high morbidity and mortality. Although glucocorticoids are the standard treatment, only half of patients achieve complete remission. Thus, there is an urgent need to screen biomarkers for the diagnosis of aGVHD to assist in the identification of individuals at risk of aGVHD.

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The tire-rubber-derived ozonation product of -(1,3-dimethylbutyl)-'-phenyl--phenylenediamine (6PPD), -(1,3-dimethylbutyl)-'-phenyl--phenylenediamine-quinone (6PPD-Q), was recently discovered to cause acute mortality in coho salmon (). -Phenylenediamines (PPDs) with variable side chains distinct from 6PPD have been identified as potential replacement antioxidants, but their toxicities remain unclear under environmentally relevant ozone conditions. We herein tested the multiphase gas-surface ozone reactivity of four select PPDs [6PPD, -isopropyl-'-phenyl--phenylenediamine (IPPD), ,'-diphenyl--phenylenediamine (DPPD), and -phenyl-'-cyclohexyl--phenylenediamine (CPPD)] and evaluated the toxicity of their reaction mixtures in coho salmon, rainbow trout (), and fathead minnow ().

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Aryl ketones are often used as photosensitizers and photoinitiators. Free radical intermediates have been suggested, but not confirmed, to be generated after photoirradiation. Here we found, unexpectedly, that a persistent radical was produced from di-2-pyridyl ketone after UV irradiation, which was detected by the direct ESR method.

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There has been widespread concern about the health hazards of per- and polyfluoroalkyl substances (PFAS), which may be the risk factor for hyperuricemia with evidence still insufficient in the general population in China. Here, we conducted a nationwide study involving 9,580 adults aged 18 years or older from 2017 to 2018, measured serum concentrations of uric acid and PFAS (PFOA, PFOS, 6:2 Cl-PFESA, PFNA, PFHxS) in participants, to assess the associations of individual PFAS with hyperuricemia, and estimated a joint effect of PFAS mixtures. We found positive associations of higher serum PFAS with elevated odds of hyperuricemia in Chinese adults, with the greatest contribution from PFOA (69.

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Background: Perfluoroalkyl and polyfluoroalkyl substance (PFAS) has endocrine-disrupting properties and may affect blood pressure. Endogenous hormones also play a crucial role in the progression of hypertension. However, their interaction with hypertension remains to be explored.

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Article Synopsis
  • This study investigates the impact of seafood intake and exposure to harmful substances called PFASs on diabetes risk, using data from over 10,000 adults in China.
  • Seafood consumers had nearly double the levels of PFASs compared to non-consumers, which is linked to higher rates of prediabetes and diabetes.
  • Despite the increased PFASs levels, the study suggests that consuming seafood may actually help reduce the negative effects of PFASs on blood sugar levels, indicating a potential dietary strategy to lower diabetes risk.
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  • Heavy metals and metalloids (HMMs) are prevalent in the environment, but their effects on liver health in China haven't been clearly documented.
  • The study analyzed data from over 9,000 Chinese adults to assess the relationship between HMM concentrations in blood and urine and liver function biomarkers like albumin and liver enzymes.
  • Results indicated that certain metals, notably manganese and thallium, could pose a risk to liver health, while selenium might offer protection; the findings suggest a need for greater public health awareness regarding low-level HMM exposure.
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Dual-wavelength digital holography effectively expands the measurement range of digital holography, but it increases the complexity of optical system due to non-common-path of two wavelengths. Here, by using orthogonal polarization strategy, we present a dual-wavelength digital holography based on a Wollaston prism (DWDH-WP) to separate the reference beams of two wavelengths and realize the common-path of two wavelengths. A Wollaston prism is inset into the reference beam path of the off-axis digital holography system, so two orthogonal-polarized reference beams of two different wavelengths separated at different directions are generated.

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Molecular pathology and clinical characteristics play a crucial role in guiding treatment selection and predicting the prognosis of diffuse large B-cell lymphoma (DLBCL). The programmed cell death protein 1 (PD-1) and its ligand (PD-L1), have emerged as pivotal regulators of immune checkpoints in cancer. The objectives of this study are to investigate the correlation between the expression levels of PD-1 and soluble PD-L1 (sPD-L1) in the peripheral blood of DLBCL patients, analyze their clinicopathological characteristics, and identify the optimal beneficiary group for PD-1/PD-L1 blockade.

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  • Antibiotics and β-receptor agonists are commonly used in medicine and animal farming, but their presence can negatively impact human health, especially in growing teenagers.
  • A study analyzed urine samples from 442 middle school students aged 11-15 to determine the levels of these drugs, revealing a high detection rate of 89.8% for at least one substance.
  • The most frequently detected drugs were doxycycline, oxytetracycline, and azithromycin, with tetracyclines and macrolides being the most prevalent antibiotic categories.
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Thyroid hormones (THs) play an important role in a wide range of crucial biological functions related to growth and development, and thyroid antibodies (TAs) can influence the biosynthesis of THs. Epidemiological studies have indicated that per- and polyfluoroalkyl substances (PFAS) could induce thyroid disruption, but studies on teenagers living in areas with high PFAS exposure are limited. This cross-sectional study focused on 836 teenagers (11- 15 years) living near a Chinese fluorochemical industrial plant.

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Background: Asthenozoospermia is the primary cause of male infertility; however, its genetic aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the testes of humans and mice and encodes a type of adenosine kinase that is functionally involved in cellular nucleotide homeostasis and energy metabolism. We aimed to assess whether AK9 is involved in asthenozoospermia.

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Acetylhydrazine (AcHZ), a major human metabolite of the widely-used anti-tuberculosis drug isoniazid (INH), was considered to be responsible for its serious hepatotoxicity and potentially fatal liver injury. It has been proposed that reactive radical species produced from further metabolic activation of AcHZ might be responsible for its hepatotoxicity. However, the exact nature of such radical species remains not clear.

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Article Synopsis
  • A novel analytical method was developed that combines automatic solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to detect 16 antibiotics and 4 -agonists in human urine samples.
  • The urine samples underwent specific preparation steps including the addition of internal standards, buffers, and enzymes, followed by a thorough extraction process that utilized Oasis PRiME HLB 96-well plates for optimal recovery rates.
  • The method was fine-tuned by testing different chromatography columns and mobile phases, achieving the best results with the HSS T column and a specific gradient elution setup using a 30% methanol aqueous solution.
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Background: The associations of legacy per- and polyfluoroalkyl substances (PFAS) with lipid metabolism are controversial, and there is little information about the impact of emerging PFAS (6:2 Cl-PFESA) on lipid metabolism in China.

Objectives: We aimed to explore the associations of legacy and emerging PFAS with lipid profiles and dyslipidemia in Chinese adults.

Methods: We included 10,855 Chinese participants aged 18 years and above in the China National Human Biomonitoring.

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Article Synopsis
  • mHealth apps in China gained popularity during the COVID-19 pandemic, addressing both medical needs and chronic disease management, but lacked thorough evaluations until now.
  • A survey of 1,593 mHealth applications analyzed their data flow, user experience, and the impact of COVID-19 on app usage before and after the outbreak.
  • Post-pandemic, rehabilitation support emerged as the most downloaded app function, while maternal and child health-related apps significantly increased in usage and interest.
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A method for the determination of 14 polybrominated diphenyl ethers (PBDEs) in human serum using isotope internal standard-gas chromatography-high resolution dual-focus magnetic mass spectrometry (GC-HRMS) was developed. After thawed to room temperature, 0.5 mL serum samples were mixed with C-labeled isotopic internal standard.

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