Specific interactions between the alkaline protease of P. aeruginosa and its natural peptide inhibitor: ab initio molecular simulations.

Alkaline protease aeruginolysin (APR) is an important virulence factor in the evasion of the immune system by Pseudomonas aeruginosa (P. aeruginosa). The P.

The GABA Receptor-Structure, Ligand Binding and Drug Development.

The γ-aminobutyric acid (GABA) type B receptor (GABA-R) belongs to class C of the G-protein coupled receptors (GPCRs). Together with the GABA receptor, the receptor mediates the neurotransmission of GABA, the main inhibitory neurotransmitter in the central nervous system (CNS). In recent decades, the receptor has been extensively studied with the intention being to understand pathophysiological roles, structural mechanisms and develop drugs.

Exploring Conformational Dynamics of the Extracellular Domain of the GABA Receptor: A Path-Metadynamics Study.

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS). Dysfunctional GABAergic neurotransmission is associated with numerous neurological and neuropsychiatric disorders. The GABA receptor (GABA-R) is a heterodimeric class C G protein-coupled receptor (GPCR) comprised of GABA and GABA subunits.